Applications and Products

How Archer NGS kits, controls and QC assays are being used.



Aug
29
2018

New features in Archer Analysis 6.0

Archer Analysis has been updated to version 6.0, making it more powerful and versatile than ever.


Aug
1
2018

High coverage and noise characterization of CEBPA for sensitive and specific variant detection

CEBPA mutations are important prognostic indicators in AML, however detecting CEBPA mutations by NGS is challenging due to high GC content. Here, we show that AMP-based NGS provides superior coverage of CEBPA and we demonstrate the use of normalization datasets to assess the noise at each base position to calculate the per-base variant detection sensitivity across CEBPA, expressed as 95 MDAF.


Apr
4
2018

Cancer and ALK, RET, ROS1 gene fusions

Cancer is caused by mutations in specific genes. Many of these genes, including ALK, RET and ROS1, are called driver oncogenes because they are critical to the survival, growth and proliferation of cancer cells


Mar
20
2018

Full BRCA coverage to detect pathogenic variants by NGS

Full BRCA coverage to detect pathogenic variants by NGS


Feb
26
2018

NGS assays that match the pace of discovery

The modularity of Archer’s AMP chemistry allows users to create personalized NGS panels with the utmost flexibility and confidence. With coverage, panel uniformity and on-target reads at >90%, your custom assay is guaranteed to work for your applications. Additionally, any Archer assay is future-proof. When your team decides upon an updated list of key gene targets, simply add gene targets to an existing panel, or create an entirely new custom panel, without sacrificing performance.


Oct
2
2017

Input considerations for TCR and BCR sequencing

NGS is a powerful method to investigate the immune repertoire, and using RNA as the starting material has several advantages over DNA. Plus, sample-specific cell distributions and cell type-specific mRNA variations should be considered when analyzing the functional immune repertoire to minimize erroneous clonotyping.


Sep
12
2017

Archer® Analysis tool: CNV Visualization in v5.1

The CNV visualization tool within Archer Analysis was designed to maximize analytical capabilities for a variety of NGS library preparations. By giving the user the ability to customize the sensitivity settings based on assay and normalization requirements, copy number gains and losses, in addition to novel variants, can be detected with exon-level resolution and effortlessly tracked within the database.


Sep
8
2017

FLT3-ITD Detection Tech Note

ArcherDX scientists developed Archer® VariantPlex® myeloid assays to detect FLT3-ITDs, along with other myeloid-specific variants, by targeted next-generation sequencing (NGS). A new technical note discusses how Anchored Multiplex PCR (AMP™) chemistry in conjunction with the data-optimized analysis algorithm in Archer Analysis enable accurate detection of FLT3-ITDs across all sizes and insertion sites from clinical-type samples with 100% accuracy.


Aug
14
2017

AMPlify your immune repertoire sequencing

AMP enrichment chemistry and Archer Analysis software reduce PCR bias and minimize PCR and sequencing errors that plague amplicon-based approaches by delivering reliable BCR and TCR sequencing. Immunoverse TCR and BCR kits enable quantitative and sensitive clonotype detection, with sequences detectable at fractions as low as one in a million. Coupled with the fully automated Archer Analysis software and user-owned data, a wide variety of research applications are available to you.


Apr
12
2016

Comprehensive Thyroid and Lung (CTL) kits enable parallel detection of copy number variants and expression levels by next-generation sequencing

CNVs are common oncogenic drivers in lung cancer that result in altered expression profiles. Here, we show that AMP™ enables sensitive NGS-based detection of CNVs and expression profiling of multiple genes relevant to lung cancer.

How to contact us

Address

2477 55th Street, Suite 202

Boulder, CO 80301

Phone

Phone: (877) 771 1093

Phone: (303) 357 9001

All content © 2018 ArcherDX, Inc.

For Research Use Only. Not for use in diagnostic procedures. For Research Use Only. Not for use in diagnostic procedures.