VariantPlex Complete Solid Tumor

Complete Solid Tumor

The VariantPlex Complete Solid Tumor panel is a targeted next-generation sequencing (NGS) assay that simultaneously detects and characterizes copy number variations (CNVs), single-nucleotide variants (SNVs), insertions and deletions (indels), microsatellite instability (MSI) status, and tumor mutational burden (TMB) in 430 cancer-implicated genes, including non-small cell lung cancer, colorectal cancer, breast cancer, bladder cancer, gastric cancer, pancreatic cancer, prostate cancer, ovarian and uterine cancers, CNS cancers, cholangiocarcinoma and melanoma. Representing our most comprehensive DNA-based assay for solid tumor research, this newly expanded panel was thoughtfully designed based on guidelines, literature, and customer input, and offers analytically sensitive variant detection even with low sample input. 

  • Key Features
  • Specifications
  • Gene Targets
  • Additional Resources
Outlier Detection

Archer’s unique outlier detection algorithm leverages position-specific data to enable confident reporting at low allele frequencies.

Customization

Create from scratch or modify any panel to keep up with the pace of discovery.

Low Input

Anchored Multiplex PCR (AMP™) chemistry was purpose-built for wide sample type compatibility, including low-input and degraded samples such as FFPE tissue.

Simple, Lyophilized Workflow

Easy-to-handle lyophilized reagents and a simple workflow to minimize errors and reduce turnaround time.

Properties

Specifications

Gene Targets
430 + MSI + TMB
Input DNA Required*
≤10ng
Recommended # of reads
45M
Hands-On Time
<3.5 hours
Total Time
1.5 days
Platform
Illumina
Sample Types
FFPE, fresh frozen, cytology smear, FNA

*Input mass requirements vary depending on type and quality. Unless the tumor cellularity and sample quality are high, 50ng of FFPE-derived nucleic acid should be considered the minimum recommendation. If input is not limiting, 200ng is recommended.

ABL1 BLM CHD4 EPHB1 FGFR4 HOXB13 KRT222 MUC16 PGR PTPRC SDHC TCF7L2
ABL2 BMPR1A CHD8 ERBB2 FH HRAS LAMP1 MUC6 PHF6 PTPRD SDHD TERT
ACVR1 BRAF CHEK1 ERBB3 FLCN HUWE1 LATS1 MUTYH PIK3C2B PTPRT SETBP1 TET1
ACVR2A BRCA1 CHEK2 ERBB4 FLNA IDH1 LATS2 MYC PIK3C2G RAC1 SETD2 TET2
AKT1 BRCA2 CIC ERCC1 FLT1 IDH2 LEMD2 MYCL PIK3CA RAD21 SF3B1 TFRC
AKT2 BRIP1 COL5A1 ERCC2 FLT3 IGF1R LRP1B MYCN PIK3CB RAD50 SH2D1A TGFBR1
AKT3 BTG1 CREBBP ERCC4 FLT4 IKBKE LZTR1 MYD88 PIK3CD RAD51 SLX4 TGFBR2
ALK BTG2 CRKL ERG FOXA1 IKZF1 MACF1 MYH9 PIK3CG RAD51B SMAD2 TGIF1
APC BTK CSDE1 ERRFI1 FOXA2 IL6ST MAP2K1 NBN PIK3R1 RAD51C SMAD3 THRAP3
AR CACNA1A CSF1R ESR1 FOXL2 IL7R MAP2K2 NCOR1 PIK3R2 RAD51D SMAD4 TLR4
ARAF CARD11 CSF3R EWSR1 FOXO1 INPP4B MAP2K4 NF1 PIK3R3 RAD52 SMARCA4 TMSB4X
ARHGAP35 CASP8 CTCF EZH2 FOXP1 INPPL1 MAP3K1 NF2 PIM1 RAD54L SMARCB1 TNFAIP3
ARID1A CBFB CTLA4 FAM175A FOXQ1 IRF2 MAP3K13 NFE2L2 PLCB4 RAF1 SMC1A TNFRSF14
ARID1B CBL CTNNA1 FAM46C FUBP1 IRF4 MAP3K4 NFKBIA PLCG1 RARA SMC3 TP53
ARID2 CCND1 CTNNB1 FAM46D GATA1 IRF6 MAPK1 NIPBL PLXNB2 RASA1 SMO TP63
ARID5B CCND2 CUL3 FANCA GATA2 IRS2 MAX NKX2-1 PMS1 RB1 SOCS1 TRAF3
ASXL1 CCND3 CYSLTR2 FANCC GATA3 JAK1 MCL1 NOTCH1 PMS2 RBM10 SOX17 TRAF7
ASXL2 CCNE1 DAXX FANCD2 GEN1 JAK2 MDM2 NOTCH2 POLD1 RECQL4 SOX2 TSC1
ATM CD274 DDR2 FANCE GLI1 JAK3 MDM4 NOTCH3 POLE REL SOX9 TSC2
ATR CD70 DDX3X FANCF GNA11 JUN MECOM NOTCH4 POLQ RET SPEN TSHR
ATRX CD79A DICER1 FANCG GNA13 KANSL1 MED12 NPM1 POLRMT RHEB SPOP TXNIP
AURKA CD79B DMD FANCI GNAQ KDM5A MEF2B NRAS PPARG RHOA SPTA1 U2AF1
AURKB CDC73 DNMT3A FANCL GNAS KDM5C MEN1 NSD1 PPM1D RICTOR SPTAN1 UNCX
AXIN1 CDH1 DOT1L FAT1 GPS2 KDM6A MET NTRK1 PPP2R1A RIT1 SRC USP9X
AXIN2 CDK12 EEF1A1 FBXW7 GRIN2D KDR MGA NTRK2 PPP2R2A RNF43 SRSF2 VHL
AXL CDK4 EEF2 FGF1 GRM3 KEAP1 MGMT NTRK3 PPP6C ROS1 STAG1 WT1
B2M CDK6 EGFR FGF19 H3F3A KEL MITF NUP93 PRDM1 RPL5 STAG2 XPO1
BAP1 CDK8 EGR3 FGF2 H3F3B KIF1A MLH1 PALB2 PRKAR1A RPS6KB1 STAT3 XRCC2
BARD1 CDKN1A EIF1AX FGF3 H3F3C KIT MLLT3 PARP1 PRKD1 RPTOR STK11 XRCC3
BCL2 CDKN1B ELF3 FGF4 HGF KLF4 MPL PAX5 PRKDC RRAS2 SUFU ZBTB20
BCL2L1 CDKN2A EP300 FGF7 HIST1H1C KLF5 MRE11A PAX8 PSIP1 RUNX1 SYK ZFHX3
BCL2L11 CDKN2B EPAS1 FGF8 HIST1H1E KMT2A MSH2 PBRM1 PTCH1 RUNX1T1 TAF1 ZMYM2
BCL6 CDKN2C EPCAM FGF9 HIST1H2BD KMT2B MSH3 PDCD1 PTEN RXRA TBL1XR1 ZMYM3
BCOR CEBPA EPHA2 FGFR1 HIST1H3B KMT2C MSH6 PDCD1LG2 PTMA SCAF4 TBX3 ZNF750
BCORL1 CHD1 EPHA3 FGFR2 HIST1H3C KMT2D MST1R PDGFRA PTPDC1 SDHA TCEB1
BIRC3 CHD3 EPHA7 FGFR3 HNF1A KRAS MTOR PDGFRB PTPN11 SDHB TCF3
Product Information
The FusionPlex Lung v2 panel Assay Marketplace
Customize this panel by adding any of our functionally-tested designs. Assay Marketplace lets you browse our catalog of targeted AMP chemistry-based panels, modify an existing panel with additional targets, or create a new panel that fits your exact requirements.

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