Archer VariantPlex
Core Myeloid Kit

37 genes targeting critical AML, MPN and MDS markers

The VariantPlex Core Myeloid panel is a 37 gene targeted sequencing panel for critical AML, MPN and MDS markers. Powered by Anchored Multiplex PCR (AMP™) chemistry, the panel enables deep strand-specific amplification of molecular barcoded DNA fragments for Illumina® sequencing. After sequencing, Archer Analysis bioinformatics software deduplicates reads into unique starting molecules, correcting for sequencing and PCR-derived errors — enabling confident and sensitive mutation detection.
For Research Use Only. Not for use in diagnostic procedures.

Highlights

  • Confident, molecular barcode driven variant detection
  • Robust FLT3-ITD detection of all sizes and insertion points
  • Outstanding coverage, including challenging genes like CEBPA
  • Simple, lyophilized single day library preparation

Product Information


FAQs Archer Analysis

Watch the video: FLT3-ITD Detection With Archer® Blood Cancer Assays

The molecular landscape of leukemia and lymphoma has expanded exponentially in the last two decades, and the complexity and scope of biomarkers makes molecular analysis difficult for any single approach. Archer Blood Cancer assays are powered by Anchored Multiplex PCR (AMP™) target enrichment chemistry to detect multiple mutation types and gene expression profiling in a single sample.

 




VariantPlex Core Myeloid Kit Features

37

Target genes

49kb

Total target size

>99%

Coverage uniformity > 20% mean

2.5 hours

Hands-on time

50-400ng‡

Input DNA required

3M

Recommended # of reads

6 hours

Time required

99%

On-target

Illumina®

Platform

FFPE, bone marrow, blood, PBL

Sample type

‡input recommendations for FFPE samples varies depending on Archer Preseq™ DNA QC score. 50ng input recommended in absence of PreSeq screening



Archer VariantPlex Core Myeloid Kit Targets

ABL1CSF3RGATA2NRASTET2
ANKRD26DDX41IDH1PHF6TP53
ASXL1DNMT3AIDH2PTPN11U2AF1
BCORETNK1JAK2RUNX1WT1
BRAFETV6KITSETBP1ZRSR2
CALREZH2KRASSF3B1
CBLFLT3MPLSRSF2
CEBPAGATA1NPM1STAG2

Need to modify a panel?

AMP chemistry is flexible and gene-level probe sets are modular. This means that any of our 94 wet lab-validated designs can be added to any preconfigured panel to build assays that fit your research goals. Archer Assay Designer gives you the power to easily determine assay content and keep current with the latest research.



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If you have any technical questions, please reach out to our expert Technical Support staff through tech@archerdx.com or by calling ArcherDX directly at +1.303.357.9001.


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How to contact us

Address

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Boulder, CO 80301

Phone

Phone: (877) 771 1093

Phone: (303) 357 9001

All content © 2017 ArcherDX, Inc.

For Research Use Only. Not for use in diagnostic procedures. For Research Use Only. Not for use in diagnostic procedures.