The VariantPlex Myeloid panel is a 74-gene targeted sequencing panel for AML, MPN, MDS and some Lymphoid malignancy markers. Powered by Anchored Multiplex PCR (AMP™) chemistry, the panel enables deep strand-specific amplification of molecular barcoded DNA fragments for Illumina Sequencing. After sequencing, Archer Analysis deduplicates reads into unique starting molecules, correcting for sequencing and PCR-derived errors--enabling sensitive and confident mutation detection.
For Research Use Only. Not for use in diagnostic procedures.
The molecular landscape of leukemia and lymphoma has expanded exponentially in the last two decades, and the complexity and scope of biomarkers makes molecular analysis difficult for any single approach. Archer Blood Cancer assays are powered by Anchored Multiplex PCR (AMP™) target enrichment chemistry to detect multiple mutation types and gene expression profiling in a single sample.
Total target size
Coverage uniformity > 20% mean†
Input DNA required
Recommended # of reads†
FFPE, bone marrow, blood, PBL
†Coverage uniformity and recommended number of reads expected.
‡input recommendations for FFPE samples varies depending on Archer Preseq™ DNA QC score. 50ng input recommended in absence of PreSeq screening
Genes in red are expected targets for CNV detection
AMP chemistry is flexible and gene-level probe sets are modular. This means that any of our 94 wet lab-validated designs can be added to any preconfigured panel to build assays that fit your research goals. Archer Assay Designer gives you the power to easily determine assay content and keep current with the latest research.
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