Powered by Anchored Multiplex PCR (AMP™) and state-of-the-art bioinformatics, Archer® VariantPlex® Myeloid assays are expertly designed to provide unprecedented confidence in mutation detection for myeloid malignancies.
Not available in Germany
For Research Use Only. Not for use in diagnostic procedures.
ASXL1, CEBPA, DNMT3A, FLT3, IDH1, IDH2, JAK2, KIT, NPM1
Includes all Core AML genes plus:
ABL1, BCOR, BRAF, CALR, CBL, CSF3R, DDX41, ETNK1, ETV6, EZH2, GATA1, GATA2, KRAS, MPL, NRAS, PHF6, PTPN11, SF3B1, SRSF2, STAG2, TET2, TP53, U2AF1, WT1, ZRSR2
Includes all Core Myeloid genes plus:
ANKRD26, ATRX, BCORL1, BTK, CBLB, CBLC, CCND2, CDKN2A, CUX1, CXCR4, DCK, DHX15, ERG, FBXW7, GNAS, HRAS, IKZF1, JAK1, JAK3, KDM6A, KMT2A, LUC7L2, MAP2K1, MYC, MYD88, NF1, NOTCH1, PML, PPM1D, PTEN, RAD21, RBBP6, RIT1, RPS14, SETBP1, SH2B3, SLC29A1, SMC1A, SMC3, STAT3, U2AF2, XPO1
AMP chemistry is flexible and gene-level probe sets are modular. This means that any of our 94 wet lab-validated designs can be added to any preconfigured panel to build assays that fit your research goals. Archer Assay Designer gives you the power to easily determine assay content and keep current with the latest research.
Independent and bidirectional probes are specifically optimized to detect internal tandem duplications (ITDs) of all sizes. The reads originating from these probes are bioinformatically assembled by Archer Analysis using a de novo assembler to form longer consensus sequences that span the ITD. These longer sequences are then aligned to the reference genome to identify the presence of even very large ITDs (> 250bp).a
a Only available on Illumina® instruments
Complete, strand-specific and bi-directional coverage of target exons, including traditionally difficult regions like CEBPA.
Powerful analysis of complex variants like CALR deletions can be detected using Archer Analysis due to the unique benefits of Anchored Multiplex PCR and extensive testing with positive samples and in-silico read generation technology.
Molecular barcodes enable sequencing and PCR error correction and unique molecule-derived sensitivity and specificity at any position for confident variant detection at lower allelic frequencies.
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