Archer VariantPlex
Myeloid NGS Assays

Powered by Anchored Multiplex PCR (AMP™) and state-of-the-art bioinformatics, Archer® VariantPlex® Myeloid assays are expertly designed to provide unprecedented confidence in mutation detection for myeloid malignancies.

Assay Features

  • Confident, molecular barcode-driven variant detection
  • Robust FLT3-ITD detection of all sizes and insertion points
  • Outstanding coverage, including challenging genes like CEBPA
  • Simple, lyophilized, single-day library preparation

Not available in Germany

For Research Use Only. Not for use in diagnostic procedures. For Research Use Only. Not for use in diagnostic procedures.

Archer VariantPlex Myeloid Panels

Core AML


10

10 genes

ASXL1, CEBPA, DNMT3A, FLT3, IDH1, IDH2, JAK2, KIT, NPM1

Core Myeloid

37

37 genes

Includes all Core AML genes plus:


ABL1, BCOR, BRAF, CALR, CBL, CSF3R, DDX41, ETNK1, ETV6, EZH2, GATA1, GATA2, KRAS, MPL, NRAS, PHF6, PTPN11, SF3B1, SRSF2, STAG2, TET2, TP53, U2AF1, WT1, ZRSR2

Myeloid

72

72 genes

Includes all Core Myeloid genes plus:


ANKRD26, ATRX, BCORL1, BTK, CBLB, CBLC, CCND2, CDKN2A, CUX1, CXCR4, DCK, DHX15, ERG, FBXW7, GNAS, HRAS, IKZF1, JAK1, JAK3, KDM6A, KMT2A, LUC7L2, MAP2K1, MYC, MYD88, NF1, NOTCH1, PML, PPM1D, PTEN, RAD21, RBBP6, RIT1, RPS14, SETBP1, SH2B3, SLC29A1, SMC1A, SMC3, STAT3, U2AF2, XPO1

Need to modify a panel?

AMP chemistry is flexible and gene-level probe sets are modular. This means that any of our 94 wet lab-validated designs can be added to any preconfigured panel to build assays that fit your research goals. Archer Assay Designer gives you the power to easily determine assay content and keep current with the latest research.


AMP-enabled FLT3-ITD detection

FLT3 detection by Archer VariantPlex Myeloid assays
FLT3 internal tandem duplications detected by Archer VariantPlex Myeloid assays
Independent and bidirectional probes are specifically optimized to detect internal tandem duplications (ITDs) of all sizes. The reads originating from these probes are bioinformatically assembled by Archer Analysis using a de novo assembler to form longer consensus sequences that span the ITD. These longer sequences are then aligned to the reference genome to identify the presence of even very large ITDs (> 250bp).a
a Only available on Illumina® instruments

High-complexity coverage across CEBPA

High complexity coverage over CEBPA with VariantPlex Myeloid Assays
Complete, strand-specific and bi-directional coverage of target exons, including traditionally difficult regions like CEBPA.

Robust CALR deletion detection

High complexity coverage over CALR with VariantPlex Myeloid Assays
Powerful analysis of complex variants like CALR deletions can be detected using Archer Analysis due to the unique benefits of Anchored Multiplex PCR and extensive testing with positive samples and in-silico read generation technology.

Molecular barcode-derived mutation detection confidence

Molecular barcodes enable sequencing and PCR error correction and unique molecule-derived sensitivity and specificity at any position for confident variant detection at lower allelic frequencies.


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How to contact us

Address

2477 55th Street, Suite 202

Boulder, CO 80301

Phone

Phone: (877) 771 1093

Phone: (303) 357 9001

All content © 2017 ArcherDX, Inc.

For Research Use Only. Not for use in diagnostic procedures. For Research Use Only. Not for use in diagnostic procedures.