The VariantPlex Myeloid panel is a 75-gene targeted sequencing panel for AML, MPN, MDS and some Lymphoid malignancy markers. Powered by Anchored Multiplex PCR (AMP™) chemistry, the panel enables deep strand-specific amplification of molecular barcoded DNA fragments for Illumina Sequencing. After sequencing, Archer Analysis deduplicates reads into unique starting molecules, correcting for sequencing and PCR-derived errors--enabling sensitive and confident mutation detection.
For Research Use Only. Not for use in diagnostic procedures.
Total target size
Coverage uniformity > 20% mean†
Input DNA required‡
Recommended # of reads†
FFPE, bone marrow, blood, PBL
†Coverage uniformity and recommended number of reads expected.
‡input recommendations for FFPE samples varies depending on Archer Preseq® DNA QC score. 50ng input recommended in absence of PreSeq screening
Genes in red are expected targets for CNV detection.
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Independent and bidirectional probes are optimized to detect ITDs of all sizes.The reads originating from these probes are bioinformatically assembled by Archer Analysis to form longer consensus sequences that span the ITD. These longer sequences are then aligned to the reference genome to identify the presence of even very large ITDs.
Complete, strand-specific and bi-directional coverage of target exons, including traditionally difficult regions like CEBPA.
Powerful analysis of complex variants like CALR deletions can be detected using Archer Analysis due to the unique benefits of Anchored Multiplex PCR and extensive testing with positive samples and in-silico read generation technolog.
Chromosomal arm loss is prevalent in certain myeloid malignancies (e.g., -7/7q, -5/5q, -13q, -11q and -12p/12p). The VariantPlex Myeloid panel targets key genes within these chromosomes to indicate copy loss.
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