Archer VariantPlex
Myeloid Kit

75 genes targeting critical AML, MPN, MDS and lymphoid markers

The VariantPlex Myeloid panel is a 75-gene targeted sequencing panel for AML, MPN, MDS and some Lymphoid malignancy markers. Powered by Anchored Multiplex PCR (AMP™) chemistry, the panel enables deep strand-specific amplification of molecular barcoded DNA fragments for Illumina Sequencing. After sequencing, Archer Analysis deduplicates reads into unique starting molecules, correcting for sequencing and PCR-derived errors--enabling sensitive and confident mutation detection.

For Research Use Only. Not for use in diagnostic procedures. For Research Use Only. Not for use in diagnostic procedures.


  • Confident and sensitive, unique molecule-driven variant detection
  • Robust FLT3-ITD detection of all sizes and insertion points
  • Outstanding coverage, including challenging genes like CEBPA
  • Simple, lyophilized single day library preparation
  • CNV detection for key genes in -7/7q, -5/5q, -13q, -11q, -12p/12p

Product Information

AB0109 - VariantPlex® Myeloid Starter Kit, for Illumina® - 16 reactions

AB0108 - VariantPlex® Myeloid Kit, for Illumina® - 8 reactions

Product insert Illumina® protocol
FAQs Archer Analysis
FLT3-ITD AMP tech note Get a quote

VariantPlex Myeloid Kit features


Gene targets


Total target size


Coverage uniformity > 20% mean


Input DNA required


Recommended # of reads



FFPE, bone marrow, blood, PBL

Sample type

Coverage uniformity and recommended number of reads expected.

input recommendations for FFPE samples varies depending on Archer Preseq® DNA QC score. 50ng input recommended in absence of PreSeq screening

VariantPlex Myeloid Kit targets


Genes in red are expected targets for CNV detection.

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Modify any panel with Archer Assay Designer.

VariantPlex Myeloid Kit capabilities

AMP-enabled FLT3-ITD detection

AMP-enabled FLT3-ITD detection

Independent and bidirectional probes are optimized to detect ITDs of all sizes.The reads originating from these probes are bioinformatically assembled by Archer Analysis to form longer consensus sequences that span the ITD. These longer sequences are then aligned to the reference genome to identify the presence of even very large ITDs.

High-complexity coverage across CEBPA

High-complexity coverage across CEBPA

Complete, strand-specific and bi-directional coverage of target exons, including traditionally difficult regions like CEBPA.

Robust CALR deletion detection

Robust CALR deletion detection

Powerful analysis of complex variants like CALR deletions can be detected using Archer Analysis due to the unique benefits of Anchored Multiplex PCR and extensive testing with positive samples and in-silico read generation technolog.

Sensitive and intuitive CNV detection

Sensitive and intuitive CNV detection

Chromosomal arm loss is prevalent in certain myeloid malignancies (e.g., -7/7q, -5/5q, -13q, -11q and -12p/12p). The VariantPlex Myeloid panel targets key genes within these chromosomes to indicate copy loss.

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How to contact us


2477 55th Street, Suite 202

Boulder, CO 80301


Phone: (877) 771 1093

Phone: (303) 357 9001

All content © 2018 ArcherDX, Inc.

For Research Use Only. Not for use in diagnostic procedures. For Research Use Only. Not for use in diagnostic procedures.