ALK RET ROS1 v2


The Archer® FusionPlex ALK, RET, ROS1 v2 panel is a targeted sequencing test to simultaneously detect and identify fusions and mutations of human ALK, RET and ROS1 genes. The panel is powered by Archer’s proprietary Anchored Multiplex PCR (AMP™) target enrichment chemistry to detect fusions of all genes in a single sequencing test, even without prior knowledge of fusion partners or breakpoints. The panel also detects select insertions and point mutations in ALK and RET, including those reported in cell-based tests to convey crizotinib resistance.
Key Features
Maximum utility

No prior knowledge of fusion partners and breakpoints required.

Low input requirement

Detection of known and novel gene fusions from as little as 20ng input nucleic acid.

Confident mutation calling

Objective sequence-based data compared to subjective FISH analysis.

High-quality data

Random start sites result in high-complexity libraries that yield better data analysis.

Product Information
Specifications and Performance

3

Gene Targets

> 10ng

Input Nucleic Acid Required*

2.5 hours

Hands-on Time

9 hours

Total Time

Illumina and
Ion Torrent

Platform

Fresh Frozen
or FFPE

Sample Types

*Input recommendations for FFPE samples vary depending on Archer PreSeq® RNA QC score; 50ng input recommended in absence of PreSeq screening

Gene Targets

LEGEND

SNV/Indel
Fusion, splicing or exon-skipping

NeeD to Modify Your Panel?

Add any of our wet lab-validated designs to this panel with Archer Assay Designer to build an assay that fits your exact requirements.

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