Archer DX

Products

VariantPlex® DNA Tests


Archer® VariantPlex panels combine patented enrichment chemistry, an easy workflow and powerful bioinformatics to generate target-enriched libraries from deoxyribonucleic acid (DNA) to confidently detect copy number variations (CNVs), single-nucleotide variants (SNVs) and indels by next-generation sequencing (NGS).

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FusionPlex® RNA Tests


Archer® FusionPlex panels generate target-enriched cDNA libraries from RNA to characterize gene fusions, SNVs, indels and detect expression levels by next-generation sequencing (NGS) on Illumina® and Ion Torrent™ platforms.

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CFTR


The Archer® VariantPlex CFTR panel is a targeted next-generation sequencing (NGS) test to detect known and unknown variants in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Independent, unidirectional primers amplify large genomic regions, enabling detection of select intronic variants and exonic mutations as well as large deletions that would otherwise be difficult to detect with opposing primer techniques.

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Pan-Heme


The Archer® FusionPlex Pan-Heme panel is an Anchored Multiplex PCR (AMP™)-based next-generation sequencing (NGS) test to detect and identify fusions, point mutations and expression levels from ribonucleic acid (RNA) input. The panel encompasses all targets in the FusionPlex heme panels, amounting to over 199 genes relating to lymphoid and myeloid malignancies. By using gene-specific primers to amplify into molecular barcodes ligated onto the cDNA fragment ends, both known and novel fusions can be identified.

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Lymphoma


The Archer® FusionPlex Lymphoma panel is a targeted next-generation sequencing (NGS) test to simultaneously detect and identify fusions, point mutations, and expression levels in 125 genes linked to lymphomas. Using Anchored Multiplex PCR (AMP™)-based enrichment, fusions can be identified even without prior knowledge of fusion partners or breakpoints. Additionally, select genes are targeted for molecular barcode-enabled relative expression detection and coverage over key hotspot regions.

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Myeloid


The Archer® FusionPlex Myeloid panel is a targeted next-generation sequencing (NGS) test to detect and identify fusions, point mutations and expression levels from 84 genes associated with myeloid-origin malignancies. Using Archer’s proprietary Anchored Multiplex PCR (AMP™)-based enrichment, fusions of all genes in this panel can be identified in a single sequencing test, even without prior knowledge of fusion partners or breakpoints. Additionally, select genes are targeted for molecular barcode-enabled relative expression level detection and point mutation coverage.

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Acute Lymphoblastic Leukemia (ALL)


The Archer® FusionPlex Acute Lymphoblastic Leukemia (ALL) panel is a targeted next-generation sequencing (NGS) test to detect and identify fusions, point mutations and expression levels in 81 genes associated with Acute Lymphoblastic Leukemia, including all recurrent Ph-like ALL fusion events. The panel uses Archer’s proprietary Anchored Multiplex PCR (AMP™)-based enrichment to detect fusions of all target genes in a single sequencing test, even without prior knowledge of fusion partners or breakpoints.

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