Mutations that drive tumorigenesis and disease progression can arise from any of hundreds of genes and are defined by genetic abnormalities that include gene fusions, single-nucleotide polymorphisms (SNPs), insertions/deletions (indels) and copy number variations (CNVs). Next-generation sequencing (NGS) is ideal for accurate and comprehensive mutation analysis, but traditional target enrichment methodologies were not built for large-scale mutation detection and characterization across the various mutation types.
Anchored Multiplex PCR (AMP) is proprietary target enrichment chemistry that is purpose-built for large-scale single- and multiplex mutation detection. AMP is central to the Archer™ FusionPlex™ RNA-based sequencing assay used to detect known and novel gene fusions associated with specific cancer types. The AMP chemistry is now incorporated into the Archer VarianPlex™ assay, a DNA-based sequencing assay to detect both somatic and germline mutations, including CNVs, SNPs and indels.
By combining revolutionary Anchored Multiplex PCR (AMP™) chemistry with an easy-to-use workflow and intuitive software, we are unleashing the power of translational NGS to enable accurate and scalable mutation detection.
Robust platform to enrich targeted RNA or DNA
Detect fusions, CNVs, SNPs and indels by NGS
Scalable cost- and labor-effective workflow
Comprehensive time-saving automated sequence analysis
Video - Anchored Multiplex PCR chemistry
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