How It Works
Total nucleic acid (TNA) is purified from a formalin-fixed, paraffin-embedded (FFPE) sample or a fresh frozen tissue sample. As little as 10ng TNA is then used with each panel to generate a targeted library from RNA (FusionPlex Solid Tumor) and DNA (VariantPlex Solid Tumor).
The libraries are then pooled and sequenced, and the Archer Analysis bioinformatics platform analyzes the data to identify fusions and alternative splicing events from the RNA and copy number variants (CNVs), SNVs and indels from the DNA in the sample.
With the FusionPlex and VariantPlex parallel workflow, Archer provides the tools for in-house, comprehensive sample analysis for all relevant mutations, reducing necessary input amounts, costly send outs and long turn-around times.