FusionPlex Dx

Dx

FusionPlex® Dx is an RNA-based targeted gene panel for detecting gene fusions and oncogenic isoforms implicated in the most prevalent solid tumors, especially non-small cell lung cancer (NSCLC). The panel covers ESMO-recommended targets including MET, NTRK1-3, ALK, ROS1, and RET, in addition to pan-tumor comprehensive genomic profiling, and provides highly actionable and quick therapy guidance. Coverage also includes 41 analytical targets, such as FGFR1-3 and NRG1, plus additional key targets to advance precision oncology by providing broader therapy options and optimal clinical trial enrollment. The panel is validated for use on Illumina® MiSeqDx and Illumina NextSeq 550Dx sequencers. It is powered by Anchored Multiplex PCR (AMP™) target enrichment chemistry to detect gene fusions and oncogenic isoforms in a single sequencing product, even without prior knowledge of gene fusion partners or breakpoints.

  • Key Features
  • Specifications
  • Gene Targets
  • Additional Resources
Meets Guidelines

Content meets ESMO and country-specific guidelines
for NSCLC.

Superior Fusion Detection for Better Therapy Selection

AMP RNA-based assays detect both known and novel fusions and can help you identify more patients who may be eligible for fusion-directed therapies.

Scalable and Flexible

Adaptable to flexible laboratory throughput and validated on MiseqDx and NextSeq 550Dx instruments.

Quick and Simple Workflow

Easy-to-handle lyophilized reagents and a simple workflow minimize errors and reduce turnaround time for better routine testing.

Properties

Specifications

Gene Targets
41
Sample Input
RNA/TNA
Sample Types
FFPE
Number of Reads per Library
MiSeqDx: 1-3 M, NextSeq 550 Dx: 1-3 M
Hands-On Time
Library prep ~3.5 hrs; sequencing ~1 hr
Total Time
Results on day 5, starting w/ extracted nucleic acid
Platform
MiSeqDx or NextSeq 550Dx
Product Information

ALK*

AR

ARHGAP26

AXL

BRAF

BRD3

BRD4

DNAJB1

EGFR

ERBB2

ERG

ESR1

ETV1

ETV4

ETV5

ETV6

FGFR1

FGFR2

FGFR3

MET*

NOTCH1

NOTCH2

NRG1

NTRK1*

NTRK2*

NTRK3*

NUTM1

PDGFRA

PDGFRB

PRKACA

PRKCA

RAF1

RELA

RET*

ROS1*

RSPO2

RSPO3

TMPRSS2

LEGEND

* Included in international and or local guidelines for NSCLC

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For Research Use Only. Not for use in diagnostic procedures.

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For Research Use Only. Not for use in diagnostic procedures.