LiquidPlex Dx

Dx

LiquidPlex™ Dx is a targeted gene panel for ctDNA that covers key biomarkers implicated in the most prevalent solid tumors, especially non-small cell lung cancer (NSCLC). CDx coverage includes METex14 splicing mutations in NSCLC in addition to pan-tumor comprehensive genomic profiling and provides highly actionable and quick therapy guidance. Coverage also includes 29 genes, including EGFR, KRAS, BRAF, ERBB2/HER2, ESR1, FGFR1, KRAS, NRAS and PIK3CA genes, plus additional key biomarkers to advance precision oncology by providing broader therapy options and optimal clinical trial enrollment. The panel is validated for use on Illumina® MiSeqDx and Illumina NextSeq 550Dx sequencers. It is powered by Anchored Multiplex PCR (AMP™) target enrichment chemistry for confident variant calling, even at low allele frequencies.

  • Key Features
  • Specifications
  • Gene Targets
  • Additional Resources
Meets Guidelines

Content meets ESMO and country-specific guidelines
for NSCLC.

Reliable Results You Can Trust

High sensitivity and specificity even with limited sample input and low allele frequency.

Scalable and Flexible

Adaptable to flexible laboratory throughput and validated on MiseqDx and NextSeq 550Dx instruments.

Comprehensive and actionable information

Can be used in parallel with tissue profiling to provide a broader picture of tumor heterogeneity, or as a quicker testing option while tissue biopsy is being obtained or if tissue is unavailable.

Properties

Specifications

Gene Targets
29
Sample Input
cfDNA
Sample Types
Plasma
Number of Reads per Library
MiSeqDx: 4-6 M, NextSeq 550 Dx: 4-6 M
Hands-On Time
Library prep ~2.5 hrs; sequencing ~1 hr
Total Time
Results on day 4, starting with extracted nucleic acid
Platform
MiSeqDx or NextSeq 550Dx
Product Information

AKT1

ALK

AR

BRAF*

CDK6

CTNNB1

EGFR*

ERBB2*

ERBB3

ESR1

FGFR1

FGFR2

FGFR3

HRAS

IDH1

IDH2

KIT

KRAS*

MAP2K1

MET

NRAS

NTRK1

NTRK2

NTRK3

PDGFRA

PIK3CA

RET

ROS1

TP53

CTNNB1

FGFR*

FGFR2

LEGEND

* Included in international and or local guidelines for NSCLC

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For Research Use Only. Not for use in diagnostic procedures.

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For Research Use Only. Not for use in diagnostic procedures.