Archer FusionPlex
Lung Kit


Introduction

The Archer® FusionPlex® Lung Kit is a targeted next-generation sequencing (NGS) assay to detect EGFR vIII and MET exon 14 skipping events along with prominent ALK, BRAF, FGFR, NRG1, NTRK, RET, and ROS1 fusions and select point mutations in 14 key gene targets associated with lung cancer. The kit is powered by Archer’s proprietary Anchored Multiplex PCR (AMP™) target enrichment chemistry to detect fusions in a single sequencing assay, even without prior knowledge of fusion partners or breakpoints.

Highlights

  • Key fusion detection - excellent small panel for focused interrogation of oncogenic fusion targets
  • Detect splice variants and relevant mutations - captures EGFR vIII and MET exon 14 skipping events, as well as prominent mutations in ALK, BRAF, EGFR, KRAS, RET, and ROS1
  • Sample versatility - wide sample type compatibility, including FFPE
  • Streamlined, lyophilized workflow - minimize hands-on time and replication error

For Research Use Only. Not for use in diagnostic procedures. For Research Use Only. Not for use in diagnostic procedures.



Product information

Illumina®

AB0121 - 8-reactions
AB0128 - 16-reactions - starter kit
AB0129 - 48-reactions

Archer Analysis

Local installation
Analysis Unlimited

Demo Data Get a quote

Documents

Protocol for Illumina Product Insert
Publications Posters

Specifications and performance

14

Gene targets

163

# of GSP2s

≥10ng

Input nucleic acid required*

500,000

Recommended # of reads


>97%

Unique molecular on-target %


2.5 hours

Hands-on time


9 hours

Total time

Illumina

Platform

Fresh frozen or FFPE

Sample types

*Input recommendations for FFPE samples vary depending on Archer Preseq® RNA QC score; 50ng input recommended in absence of PreSeq screening

Gene targets

AICDAExpression
BLNKExpression
CD274Expression
CTLA4Expression
DNTTExpression
HOXA10Expression
HOXA9Expression
IRF4Expression
IRF8Expression
LMO1Expression
LYL1Expression
PDCD1Expression
PTPN1Expression
RAG1Expression
RAG2Expression
SOX11Expression
TLX1Expression
TLX3Expression
BCL6ExpressionFusion
MYCExpressionFusion
PDCD1LG2ExpressionFusion
TAL1ExpressionFusion
BCL2ExpressionFusionSingle nucleotide variant (SNV) or Indel
CRLF2ExpressionFusionSingle nucleotide variant (SNV) or Indel
FLT3ExpressionSingle nucleotide variant (SNV) or Indel
WT1ExpressionSingle nucleotide variant (SNV) or Indel
ABL2Fusion
BCL11BFusion
BCRFusion
CHD1Fusion
CSF1RFusion
EBF1Fusion
EPORFusion
FGFR1Fusion
IKZF1Fusion
IKZF2Fusion
KLF2Fusion
KMT2AFusion
MLLT4Fusion
NF1Fusion
NTRK3Fusion
NUP214Fusion
NUP98Fusion
P2RY8Fusion
PAG1Fusion
PBX1Fusion
PDGFRBFusion
PICALMFusion
PTK2BFusion
RUNX1Fusion
SEMA6AFusion
SETD2Fusion
STILFusion
TCF3Fusion
ZCCHC7Fusion
CREBBPFusionSingle nucleotide variant (SNV) or Indel
ETV6FusionSingle nucleotide variant (SNV) or Indel
IKZF3FusionSingle nucleotide variant (SNV) or Indel
JAK2FusionSingle nucleotide variant (SNV) or Indel
NOTCH1FusionSingle nucleotide variant (SNV) or Indel
PAX5FusionSingle nucleotide variant (SNV) or Indel
PDGFRAFusionSingle nucleotide variant (SNV) or Indel
TYK2FusionSingle nucleotide variant (SNV) or Indel
ABL1FusionSingle nucleotide variant (SNV) or IndelExpression
BRAFSingle nucleotide variant (SNV) or Indel
DNM2Single nucleotide variant (SNV) or Indel
EZH2Single nucleotide variant (SNV) or Indel
FBXW7Single nucleotide variant (SNV) or Indel
IDH1Single nucleotide variant (SNV) or Indel
IDH2Single nucleotide variant (SNV) or Indel
IL7RSingle nucleotide variant (SNV) or Indel
JAK1Single nucleotide variant (SNV) or Indel
JAK3Single nucleotide variant (SNV) or Indel
KDM6ASingle nucleotide variant (SNV) or Indel
KRASSingle nucleotide variant (SNV) or Indel
MPLSingle nucleotide variant (SNV) or Indel
NRASSingle nucleotide variant (SNV) or Indel
NT5C2Single nucleotide variant (SNV) or Indel
PTPN11Single nucleotide variant (SNV) or Indel
SH2B3Single nucleotide variant (SNV) or Indel
STAT3Single nucleotide variant (SNV) or Indel
STAT5BSingle nucleotide variant (SNV) or Indel
CALCAExpression
KRT20Expression
KRT7Expression
PTHExpression
SLC5A5Expression
TTF1Expression
AXLFusion
CCND1Fusion
FGFR2Fusion
FGFR3Fusion
METFusion
NRG1Fusion
NTRK1Fusion
NTRK2Fusion
NTRK3Fusion
PPARGFusion
RAF1Fusion
THADAFusion
AKT1FusionSingle nucleotide variant (SNV) or Indel
ALKFusionSingle nucleotide variant (SNV) or Indel
BRAFFusionSingle nucleotide variant (SNV) or Indel
EGFRFusionSingle nucleotide variant (SNV) or Indel
FGFR1FusionSingle nucleotide variant (SNV) or Indel
RETFusionSingle nucleotide variant (SNV) or Indel
ROS1FusionSingle nucleotide variant (SNV) or Indel
CTNNB1Single nucleotide variant (SNV) or Indel
DDR2Single nucleotide variant (SNV) or Indel
ERBB2Single nucleotide variant (SNV) or Indel
GNASSingle nucleotide variant (SNV) or Indel
HRASSingle nucleotide variant (SNV) or Indel
IDH1Single nucleotide variant (SNV) or Indel
IDH2Single nucleotide variant (SNV) or Indel
KRASSingle nucleotide variant (SNV) or Indel
MAP2K1Single nucleotide variant (SNV) or Indel
NRASSingle nucleotide variant (SNV) or Indel
PIK3CASingle nucleotide variant (SNV) or Indel
BCL3Expression
CCND2Expression
CD274Expression
CDKN2AExpression
CEBPDExpression
CEBPEExpression
CEBPGExpression
CTLA4Expression
FOXP1Expression
ID4Expression
IRF4Expression
IRF8Expression
MUC1Expression
PDCD1Expression
BCL6ExpressionFusion
CCND3ExpressionFusion
MECOMExpressionFusion
MYCExpressionFusion
PDCD1LG2ExpressionFusion
TAL1ExpressionFusion
BCL2ExpressionFusionSingle nucleotide variant (SNV) or Indel
CCND1ExpressionFusionSingle nucleotide variant (SNV) or Indel
CRLF2ExpressionFusionSingle nucleotide variant (SNV) or Indel
CEBPAExpressionSingle nucleotide variant (SNV) or Indel
ABL2Fusion
BCL11BFusion
BCRFusion
CBFBFusion
CDK6Fusion
CHD1Fusion
CHIC2Fusion
CIITAFusion
CSF1RFusion
DEKFusion
DUSP22Fusion
EBF1Fusion
EIF4A1Fusion
EPORFusion
ERGFusion
FGFR1Fusion
GLIS2Fusion
IKZF1Fusion
IKZF2Fusion
KAT6AFusion
KLF2Fusion
KMT2AFusion
MALT1Fusion
MKL1Fusion
MLF1Fusion
MLLT10Fusion
MLLT4Fusion
MYH11Fusion
NF1Fusion
NFKB2Fusion
NTRK3Fusion
NUP214Fusion
NUP98Fusion
P2RY8Fusion
PAG1Fusion
PDGFRBFusion
PICALMFusion
PRDM16Fusion
PTK2BFusion
RBM15Fusion
ROS1Fusion
RUNX1Fusion
RUNX1T1Fusion
SEMA6AFusion
SETD2Fusion
STILFusion
TCF3Fusion
TFGFusion
TP63Fusion
ZCCHC7Fusion
ABL1FusionSingle nucleotide variant (SNV) or Indel
ALKFusionSingle nucleotide variant (SNV) or Indel
BIRC3FusionSingle nucleotide variant (SNV) or Indel
CREBBPFusionSingle nucleotide variant (SNV) or Indel
ETV6FusionSingle nucleotide variant (SNV) or Indel
IKZF3FusionSingle nucleotide variant (SNV) or Indel
JAK2FusionSingle nucleotide variant (SNV) or Indel
NOTCH1FusionSingle nucleotide variant (SNV) or Indel
PAX5FusionSingle nucleotide variant (SNV) or Indel
PDGFRAFusionSingle nucleotide variant (SNV) or Indel
PMLFusionSingle nucleotide variant (SNV) or Indel
RARAFusionSingle nucleotide variant (SNV) or Indel
TYK2FusionSingle nucleotide variant (SNV) or Indel
FGFR1Fusion
FGFR2Fusion
FGFR3Fusion
METFusion
NRG1Fusion
NTRK1Fusion
NTRK2Fusion
NTRK3Fusion
KRASSingle nucleotide variant (SNV) or Indel
ALKSingle nucleotide variant (SNV) or IndelFusion
BRAFSingle nucleotide variant (SNV) or IndelFusion
EGFRSingle nucleotide variant (SNV) or IndelFusion
RETSingle nucleotide variant (SNV) or IndelFusion
ROS1Single nucleotide variant (SNV) or IndelFusion
AICDAExpression
ASB13Expression
BATF3Expression
BCL2A1Expression
BCL3Expression
BLNKExpression
BMFExpression
BMP7Expression
CCDC50Expression
CCND2Expression
CD274Expression
CD44Expression
CDC25AExpression
CDKN2AExpression
CDKN2BExpression
CEBPDExpression
CEBPEExpression
CEBPGExpression
CREB3L2Expression
CTLA4Expression
CYB5R2Expression
DENND3Expression
DLEU1Expression
DNMT3BExpression
DNTTExpression
E2F2Expression
ENTPD1Expression
EXOC2Expression
FAM216AExpression
FOXP1Expression
FUT8Expression
IL16Expression
IRF4Expression
IRF8Expression
ITPKBExpression
KIAA0101Expression
LIMD1Expression
LMO2Expression
LRMPExpression
LZTS1Expression
MALExpression
MAML3Expression
MMEExpression
MUC1Expression
MYBL1Expression
NEK6Expression
NFKB1Expression
NME1Expression
PAICSExpression
PDCD1Expression
PIM1Expression
PIM2Expression
PPATExpression
PRKAR2BExpression
PTPN1Expression
PYCR1Expression
RAG1Expression
RAG2Expression
RANBP1Expression
S1PR2Expression
SERPINA9Expression
SH3BP5Expression
STRBPExpression
TNFRSF13BExpression
TNFSF4Expression
WT1Expression
MYCExpressionFusion
ALKFusion
BCRFusion
CBFBFusion
CDK6Fusion
CHIC2Fusion
CIITAFusion
DEKFusion
DUSP22Fusion
EIF4A1Fusion
FGFR1Fusion
JAK2Fusion
KMT2AFusion
MALT1Fusion
MKL1Fusion
MLF1Fusion
MLLT10Fusion
NFKB2Fusion
PDGFRAFusion
PRDM16Fusion
STILFusion
TCF3Fusion
TP63Fusion
BCL6FusionExpression
CCND3FusionExpression
PDCD1LG2FusionExpression
CCND1FusionExpressionSingle nucleotide variant (SNV) or Indel
NOTCH1FusionSingle nucleotide variant (SNV) or Indel
AKT3FusionSingle nucleotide variant (SNV) or Indel
BIRC3FusionSingle nucleotide variant (SNV) or Indel
BAXSingle nucleotide variant (SNV) or Indel
BRAFSingle nucleotide variant (SNV) or Indel
BTKSingle nucleotide variant (SNV) or Indel
CARD11Single nucleotide variant (SNV) or Indel
CD79BSingle nucleotide variant (SNV) or Indel
CREBBPSingle nucleotide variant (SNV) or Indel
DNMT3ASingle nucleotide variant (SNV) or Indel
EZH2Single nucleotide variant (SNV) or Indel
FBXW7Single nucleotide variant (SNV) or Indel
IDH1Single nucleotide variant (SNV) or Indel
IDH2Single nucleotide variant (SNV) or Indel
JAK1Single nucleotide variant (SNV) or Indel
JAK3Single nucleotide variant (SNV) or Indel
KRASSingle nucleotide variant (SNV) or Indel
MYD88Single nucleotide variant (SNV) or Indel
NOTCH2Single nucleotide variant (SNV) or Indel
NRASSingle nucleotide variant (SNV) or Indel
PLCG1Single nucleotide variant (SNV) or Indel
PLCG2Single nucleotide variant (SNV) or Indel
RHOASingle nucleotide variant (SNV) or Indel
SF3B1Single nucleotide variant (SNV) or Indel
STAT3Single nucleotide variant (SNV) or Indel
STAT5BSingle nucleotide variant (SNV) or Indel
STAT6Single nucleotide variant (SNV) or Indel
XPO1Single nucleotide variant (SNV) or Indel
ETV6Single nucleotide variant (SNV) or IndelFusion
BCL2Single nucleotide variant (SNV) or IndelFusionExpression
CD274Expression
CTLA4Expression
ID4Expression
IRF4Expression
IRF8Expression
MUC1Expression
PDCD1Expression
BCRFusion
CBFBFusion
CHD1Fusion
CHIC2Fusion
CSF1RFusion
ERGFusion
FGFR1Fusion
GLIS2Fusion
IKZF1Fusion
KAT6AFusion
KMT2AFusion
MKL1Fusion
MLLT10Fusion
MLLT4Fusion
MYH11Fusion
NF1Fusion
NUP214Fusion
NUP98Fusion
PDGFRBFusion
PICALMFusion
RBM15Fusion
ROS1Fusion
RUNX1Fusion
RUNX1T1Fusion
SETD2Fusion
TCF3Fusion
TFGFusion
MECOMFusionExpression
MYCFusionExpression
PDCD1LG2FusionExpression
ABL1FusionSingle nucleotide variant (SNV) or Indel
CREBBPFusionSingle nucleotide variant (SNV) or Indel
ETV6FusionSingle nucleotide variant (SNV) or Indel
IKZF3FusionSingle nucleotide variant (SNV) or Indel
JAK2FusionSingle nucleotide variant (SNV) or Indel
NOTCH1FusionSingle nucleotide variant (SNV) or Indel
PDGFRAFusionSingle nucleotide variant (SNV) or Indel
PMLFusionSingle nucleotide variant (SNV) or Indel
RARAFusionSingle nucleotide variant (SNV) or Indel
AKT3Single nucleotide variant (SNV) or Indel
ASXL1Single nucleotide variant (SNV) or Indel
BRAFSingle nucleotide variant (SNV) or Indel
CALRSingle nucleotide variant (SNV) or Indel
CBLSingle nucleotide variant (SNV) or Indel
CSF3RSingle nucleotide variant (SNV) or Indel
DCKSingle nucleotide variant (SNV) or Indel
DNM2Single nucleotide variant (SNV) or Indel
DNMT3ASingle nucleotide variant (SNV) or Indel
EZH2Single nucleotide variant (SNV) or Indel
FBXW7Single nucleotide variant (SNV) or Indel
FGFR2Single nucleotide variant (SNV) or Indel
FGFR3Single nucleotide variant (SNV) or Indel
GATA1Single nucleotide variant (SNV) or Indel
GATA2Single nucleotide variant (SNV) or Indel
GNASSingle nucleotide variant (SNV) or Indel
IDH1Single nucleotide variant (SNV) or Indel
IDH2Single nucleotide variant (SNV) or Indel
JAK1Single nucleotide variant (SNV) or Indel
JAK3Single nucleotide variant (SNV) or Indel
KDM6ASingle nucleotide variant (SNV) or Indel
KITSingle nucleotide variant (SNV) or Indel
KRASSingle nucleotide variant (SNV) or Indel
MPLSingle nucleotide variant (SNV) or Indel
MYD88Single nucleotide variant (SNV) or Indel
NPM1Single nucleotide variant (SNV) or Indel
NRASSingle nucleotide variant (SNV) or Indel
PHF6Single nucleotide variant (SNV) or Indel
PTPN11Single nucleotide variant (SNV) or Indel
SETBP1Single nucleotide variant (SNV) or Indel
SF3B1Single nucleotide variant (SNV) or Indel
SLC29A1Single nucleotide variant (SNV) or Indel
SRSF2Single nucleotide variant (SNV) or Indel
U2AF1Single nucleotide variant (SNV) or Indel
XPO1Single nucleotide variant (SNV) or Indel
CEBPASingle nucleotide variant (SNV) or IndelExpression
FLT3Single nucleotide variant (SNV) or IndelExpression
WT1Single nucleotide variant (SNV) or IndelExpression
ABL1Fusion
ABL2Fusion
AKT1Fusion
AKT2Fusion
AKT3Fusion
ALKFusion
ARHGAP26Fusion
AXLFusion
BRD3Fusion
BRD4Fusion
CRLF2Fusion
CSF1RFusion
EGFRFusion
EPORFusion
ERBB2Fusion
ERBB4Fusion
ERGFusion
ESR1Fusion
ETV1Fusion
ETV4Fusion
ETV5Fusion
ETV6Fusion
EWSR1Fusion
FGFR1Fusion
FGFR2Fusion
FGFR2Fusion
FGFR3Fusion
FGRFusion
IL2RBFusion
INSRFusion
JAK1Fusion
JAK2Fusion
JAK3Fusion
KITFusion
MAML2Fusion
MAST1Fusion
MAST2Fusion
MSMBFusion
MUSKFusion
MYBFusion
MYCFusion
NOTCH1Fusion
NOTCH2Fusion
NRG1Fusion
NTRK1Fusion
NTRK2Fusion
NTRK3Fusion
NTRK3Fusion
NUMBLFusion
NUTFusion
PDGFRBFusion
PIK3CAFusion
PKN1Fusion
PPARGFusion
PRKCAFusion
PRKCBFusion
PTK2BFusion
RAF1Fusion
RARAFusion
RELAFusion
RETFusion
ROS1Fusion
RSPO2Fusion
RSPO3Fusion
SYKFusion
TERTFusion
TFE3Fusion
TFEBFusion
THADAFusion
TMPRSS2Fusion
TSLPFusion
TYK2Fusion
BRAFFusionSingle nucleotide variant (SNV) or Indel
METFusionSingle nucleotide variant (SNV) or Indel
PDGFRAFusionSingle nucleotide variant (SNV) or Indel
AICDAExpression
ASB13Expression
BATF3Expression
BCL2A1Expression
BCL3Expression
BLNKExpression
BMFExpression
BMP7Expression
CCDC50Expression
CCND2Expression
CD274Expression
CD44Expression
CDC25AExpression
CDKN2AExpression
CDKN2BExpression
CEBPDExpression
CEBPEExpression
CEBPGExpression
CREB3L2Expression
CTLA4Expression
CYB5R2Expression
DENND3Expression
DLEU1Expression
DNMT3BExpression
DNTTExpression
E2F2Expression
ENTPD1Expression
EXOC2Expression
FAM216AExpression
FOXP1Expression
FUT8Expression
HOXA10Expression
HOXA9Expression
ID4Expression
IL16Expression
IRF4Expression
IRF8Expression
ITPKBExpression
KIAA0101Expression
LIMD1Expression
LMO1Expression
LMO2Expression
LRMPExpression
LYL1Expression
LZTS1Expression
MALExpression
MAML3Expression
MMEExpression
MUC1Expression
MYBL1Expression
NEK6Expression
NFKB1Expression
NME1Expression
PAICSExpression
PDCD1Expression
PIM1Expression
PIM2Expression
PPATExpression
PRKAR2BExpression
PTPN1Expression
PYCR1Expression
RAB29Expression
RAG1Expression
RAG2Expression
RANBP1Expression
S1PR2Expression
SERPINA9Expression
SH3BP5Expression
SOX11Expression
STRBPExpression
TLX1Expression
TLX3Expression
TNFRSF13BExpression
TNFSF4Expression
BCL6ExpressionFusion
CCND3ExpressionFusion
MECOMExpressionFusion
MYCExpressionFusion
PDCD1LG2ExpressionFusion
TAL1ExpressionFusion
BCL2ExpressionFusionSingle nucleotide variant (SNV) or Indel
CCND1ExpressionFusionSingle nucleotide variant (SNV) or Indel
CRLF2ExpressionFusionSingle nucleotide variant (SNV) or Indel
CEBPAExpressionSingle nucleotide variant (SNV) or Indel
FLT3ExpressionSingle nucleotide variant (SNV) or Indel
WT1ExpressionSingle nucleotide variant (SNV) or Indel
ABL2Fusion
BCL11BFusion
BCRFusion
CBFBFusion
CDK6Fusion
CHD1Fusion
CHIC2Fusion
CIITAFusion
CSF1RFusion
DEKFusion
DUSP22Fusion
EBF1Fusion
EIF4A1Fusion
EPORFusion
ERGFusion
FGFR1Fusion
GLIS2Fusion
IKZF1Fusion
IKZF2Fusion
KAT6AFusion
KLF2Fusion
KMT2AFusion
MALT1Fusion
MKL1Fusion
MLF1Fusion
MLLT10Fusion
MLLT4Fusion
MYH11Fusion
NF1Fusion
NFKB2Fusion
NTRK3Fusion
NUP214Fusion
NUP98Fusion
P2RY8Fusion
PAG1Fusion
PBX1Fusion
PDGFRBFusion
PICALMFusion
PRDM16Fusion
PTK2BFusion
RBM15Fusion
ROS1Fusion
RUNX1Fusion
RUNX1T1Fusion
SEMA6AFusion
SETD2Fusion
STILFusion
TCF3Fusion
TFGFusion
TP63Fusion
ZCCHC7Fusion
ABL1FusionSingle nucleotide variant (SNV) or Indel
ALKFusionSingle nucleotide variant (SNV) or Indel
BIRC3FusionSingle nucleotide variant (SNV) or Indel
CREBBPFusionSingle nucleotide variant (SNV) or Indel
ETV6FusionSingle nucleotide variant (SNV) or Indel
IKZF3FusionSingle nucleotide variant (SNV) or Indel
JAK2FusionSingle nucleotide variant (SNV) or Indel
NOTCH1FusionSingle nucleotide variant (SNV) or Indel
PAX5FusionSingle nucleotide variant (SNV) or Indel
PDGFRAFusionSingle nucleotide variant (SNV) or Indel
PMLFusionSingle nucleotide variant (SNV) or Indel
RARAFusionSingle nucleotide variant (SNV) or Indel
TYK2FusionSingle nucleotide variant (SNV) or Indel
AKT3Single nucleotide variant (SNV) or Indel
ASXL1Single nucleotide variant (SNV) or Indel
BAXSingle nucleotide variant (SNV) or Indel
BRAFSingle nucleotide variant (SNV) or Indel
BTKSingle nucleotide variant (SNV) or Indel
CALRSingle nucleotide variant (SNV) or Indel
CARD11Single nucleotide variant (SNV) or Indel
CBLSingle nucleotide variant (SNV) or Indel
CD79BSingle nucleotide variant (SNV) or Indel
CSF3RSingle nucleotide variant (SNV) or Indel
DCKSingle nucleotide variant (SNV) or Indel
DNM2Single nucleotide variant (SNV) or Indel
DNMT3ASingle nucleotide variant (SNV) or Indel
EZH2Single nucleotide variant (SNV) or Indel
FBXW7Single nucleotide variant (SNV) or Indel
FGFR2Single nucleotide variant (SNV) or Indel
FGFR3Single nucleotide variant (SNV) or Indel
GATA1Single nucleotide variant (SNV) or Indel
GATA2Single nucleotide variant (SNV) or Indel
GNASSingle nucleotide variant (SNV) or Indel
IDH1Single nucleotide variant (SNV) or Indel
IDH2Single nucleotide variant (SNV) or Indel
IL7RSingle nucleotide variant (SNV) or Indel
JAK1Single nucleotide variant (SNV) or Indel
JAK3Single nucleotide variant (SNV) or Indel
KDM6ASingle nucleotide variant (SNV) or Indel
KITSingle nucleotide variant (SNV) or Indel
KRASSingle nucleotide variant (SNV) or Indel
MPLSingle nucleotide variant (SNV) or Indel
MYD88Single nucleotide variant (SNV) or Indel
NOTCH2Single nucleotide variant (SNV) or Indel
NPM1Single nucleotide variant (SNV) or Indel
NRASSingle nucleotide variant (SNV) or Indel
NT5C2Single nucleotide variant (SNV) or Indel
PHF6Single nucleotide variant (SNV) or Indel
PLCG1Single nucleotide variant (SNV) or Indel
PLCG2Single nucleotide variant (SNV) or Indel
PTPN11Single nucleotide variant (SNV) or Indel
RHOASingle nucleotide variant (SNV) or Indel
SETBP1Single nucleotide variant (SNV) or Indel
SF3B1Single nucleotide variant (SNV) or Indel
SH2B3Single nucleotide variant (SNV) or Indel
SLC29A1Single nucleotide variant (SNV) or Indel
SRSF2Single nucleotide variant (SNV) or Indel
STAT3Single nucleotide variant (SNV) or Indel
STAT5BSingle nucleotide variant (SNV) or Indel
STAT6Single nucleotide variant (SNV) or Indel
U2AF1Single nucleotide variant (SNV) or Indel
XPO1Single nucleotide variant (SNV) or Indel
ALKFusion
CAMTA1Fusion
CCNB3Fusion
CICFusion
EPC1Fusion
EWSR1Fusion
FOXO1Fusion
FUSFusion
GLI1Fusion
HMGA2Fusion
JAZF1Fusion
MEAF6Fusion
MKL2Fusion
NCOA2Fusion
NTRK3Fusion
PDGFBFusion
PLAG1Fusion
ROS1Fusion
SS18Fusion
STAT6Fusion
TAF15Fusion
TCF12Fusion
TFE3Fusion
TFGFusion
USP6Fusion
YWHAEFusion
AKT3Fusion
ARHGAP26Fusion
AXLFusion
BRD3Fusion
BRD4Fusion
EGFRFusion
ERGFusion
ESR1Fusion
ETV1Fusion
ETV4Fusion
ETV5Fusion
ETV6Fusion
EWSR1Fusion
FGFR1Fusion
FGFR2Fusion
FGFR3Fusion
FGRFusion
INSRFusion
MAML2Fusion
MAST1Fusion
MAST2Fusion
METFusion
MSMBFusion
MUSKFusion
MYBFusion
NOTCH1Fusion
NOTCH2Fusion
NRG1Fusion
NTRK1Fusion
NTRK2Fusion
NTRK3Fusion
NUMBLFusion
NUTM1Fusion
PDGFRBFusion
PIK3CAFusion
PKN1Fusion
PPARGFusion
PRKCAFusion
PRKCBFusion
RAF1Fusion
RELAFusion
RETFusion
ROS1Fusion
RSPO2Fusion
RSPO3Fusion
TERTFusion
TFE3Fusion
TFEBFusion
THADAFusion
TMPRSS2Fusion
ALKFusionSingle nucleotide variant (SNV) or Indel
BRAFFusionSingle nucleotide variant (SNV) or Indel
PDGFRAFusionSingle nucleotide variant (SNV) or Indel
FLT3Copy number variation (CNV)Single nucleotide variant (SNV) or IndelInternal tandem duplication (ITD)
ABL1Single nucleotide variant (SNV) or Indel
ANKRD26Single nucleotide variant (SNV) or Indel
BRAFSingle nucleotide variant (SNV) or Indel
CALRSingle nucleotide variant (SNV) or Indel
CEBPASingle nucleotide variant (SNV) or Indel
CSF3RSingle nucleotide variant (SNV) or Indel
DDX41Single nucleotide variant (SNV) or Indel
DNMT3ASingle nucleotide variant (SNV) or Indel
ETNK1Single nucleotide variant (SNV) or Indel
EZH2Single nucleotide variant (SNV) or Indel
GATA1Single nucleotide variant (SNV) or Indel
GATA2Single nucleotide variant (SNV) or Indel
IDH1Single nucleotide variant (SNV) or Indel
IDH2Single nucleotide variant (SNV) or Indel
JAK2Single nucleotide variant (SNV) or Indel
KITSingle nucleotide variant (SNV) or Indel
KRASSingle nucleotide variant (SNV) or Indel
MPLSingle nucleotide variant (SNV) or Indel
NPM1Single nucleotide variant (SNV) or Indel
NRASSingle nucleotide variant (SNV) or Indel
PHF6Single nucleotide variant (SNV) or Indel
PTPN11Single nucleotide variant (SNV) or Indel
SETBP1Single nucleotide variant (SNV) or Indel
SF3B1Single nucleotide variant (SNV) or Indel
SRSF2Single nucleotide variant (SNV) or Indel
STAG2Single nucleotide variant (SNV) or Indel
ASXL1Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
CBLSingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
ETV6Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
RUNX1Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
TET2Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
TP53Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
U2AF1Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
WT1Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
ZRSR2Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
BCORSingle nucleotide variant (SNV) or IndelCopy number variation (CNV)Internal tandem duplication (ITD)
CCND1Copy number variation (CNV)
MDM2Copy number variation (CNV)
ERBB2Copy number variation (CNV)Single nucleotide variant (SNV) or Indel
AKT1Single nucleotide variant (SNV) or Indel
ALKSingle nucleotide variant (SNV) or Indel
BRAFSingle nucleotide variant (SNV) or Indel
CTNNB1Single nucleotide variant (SNV) or Indel
DDR2Single nucleotide variant (SNV) or Indel
EIF1AXSingle nucleotide variant (SNV) or Indel
FGFR1Single nucleotide variant (SNV) or Indel
FGFR2Single nucleotide variant (SNV) or Indel
FGFR3Single nucleotide variant (SNV) or Indel
GNASSingle nucleotide variant (SNV) or Indel
HRASSingle nucleotide variant (SNV) or Indel
IDH1Single nucleotide variant (SNV) or Indel
IDH2Single nucleotide variant (SNV) or Indel
KITSingle nucleotide variant (SNV) or Indel
KRASSingle nucleotide variant (SNV) or Indel
MAP2K1Single nucleotide variant (SNV) or Indel
METSingle nucleotide variant (SNV) or Indel
NRASSingle nucleotide variant (SNV) or Indel
PDGFRASingle nucleotide variant (SNV) or Indel
PIK3CASingle nucleotide variant (SNV) or Indel
PTENSingle nucleotide variant (SNV) or Indel
ROS1Single nucleotide variant (SNV) or Indel
STK11Single nucleotide variant (SNV) or Indel
TERTSingle nucleotide variant (SNV) or Indel
TP53Single nucleotide variant (SNV) or Indel
TSHRSingle nucleotide variant (SNV) or Indel
ALKSingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
DDR2Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
EGFRSingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
FGFR1Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
FGFR2Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
FGFR3Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
GNASSingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
KITSingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
KRASSingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
METSingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
NRASSingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
PDGFRASingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
PIK3CASingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
PTENSingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
RETSingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
STK11Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
TP53Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
FLT3Copy number variation (CNV)Single nucleotide variant (SNV) or IndelInternal tandem duplication (ITD)
ABL1Single nucleotide variant (SNV) or Indel
ANKRD26Single nucleotide variant (SNV) or Indel
ATRXSingle nucleotide variant (SNV) or Indel
BCORL1Single nucleotide variant (SNV) or Indel
BRAFSingle nucleotide variant (SNV) or Indel
BTKSingle nucleotide variant (SNV) or Indel
CALRSingle nucleotide variant (SNV) or Indel
CBLBSingle nucleotide variant (SNV) or Indel
CBLCSingle nucleotide variant (SNV) or Indel
CCND2Single nucleotide variant (SNV) or Indel
CEBPASingle nucleotide variant (SNV) or Indel
CSF3RSingle nucleotide variant (SNV) or Indel
CXCR4Single nucleotide variant (SNV) or Indel
DCKSingle nucleotide variant (SNV) or Indel
DDX41Single nucleotide variant (SNV) or Indel
DHX15Single nucleotide variant (SNV) or Indel
DNMT3ASingle nucleotide variant (SNV) or Indel
ETNK1Single nucleotide variant (SNV) or Indel
EZH2Single nucleotide variant (SNV) or Indel
FBXW7Single nucleotide variant (SNV) or Indel
GATA1Single nucleotide variant (SNV) or Indel
GATA2Single nucleotide variant (SNV) or Indel
GNASSingle nucleotide variant (SNV) or Indel
HRASSingle nucleotide variant (SNV) or Indel
IDH1Single nucleotide variant (SNV) or Indel
IDH2Single nucleotide variant (SNV) or Indel
JAK2Single nucleotide variant (SNV) or Indel
JAK3Single nucleotide variant (SNV) or Indel
KITSingle nucleotide variant (SNV) or Indel
KMT2ASingle nucleotide variant (SNV) or Indel
KRASSingle nucleotide variant (SNV) or Indel
MAP2K1Single nucleotide variant (SNV) or Indel
MPLSingle nucleotide variant (SNV) or Indel
MYD88Single nucleotide variant (SNV) or Indel
NOTCH1Single nucleotide variant (SNV) or Indel
NPM1Single nucleotide variant (SNV) or Indel
NRASSingle nucleotide variant (SNV) or Indel
PDGFRASingle nucleotide variant (SNV) or Indel
PHF6Single nucleotide variant (SNV) or Indel
PPM1DSingle nucleotide variant (SNV) or Indel
PTENSingle nucleotide variant (SNV) or Indel
PTPN11Single nucleotide variant (SNV) or Indel
RBBP6Single nucleotide variant (SNV) or Indel
SETBP1Single nucleotide variant (SNV) or Indel
SF3B1Single nucleotide variant (SNV) or Indel
SH2B3Single nucleotide variant (SNV) or Indel
SLC29A1Single nucleotide variant (SNV) or Indel
SMC1ASingle nucleotide variant (SNV) or Indel
SMC3Single nucleotide variant (SNV) or Indel
SRSF2Single nucleotide variant (SNV) or Indel
STAG2Single nucleotide variant (SNV) or Indel
STAT3Single nucleotide variant (SNV) or Indel
U2AF2Single nucleotide variant (SNV) or Indel
XPO1Single nucleotide variant (SNV) or Indel
ASXL1Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
CBLSingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
CDC25CSingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
CDKN2ASingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
CUX1Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
ETV6Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
IKZF1Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
KDM6ASingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
LUC7L2Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
MYCSingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
NF1Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
RAD21Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
RPS14Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
RUNX1Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
TET2Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
TP53Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
U2AF1Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
WT1Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
ZRSR2Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
BCORSingle nucleotide variant (SNV) or IndelCopy number variation (CNV)Internal tandem duplication (ITD)
CCND1Copy number variation (CNV)
MDM2Copy number variation (CNV)
MYCCopy number variation (CNV)
MYCNCopy number variation (CNV)
AKT1Single nucleotide variant (SNV) or Indel
BRAFSingle nucleotide variant (SNV) or Indel
CSF1RSingle nucleotide variant (SNV) or Indel
CTNNB1Single nucleotide variant (SNV) or Indel
ESR1Single nucleotide variant (SNV) or Indel
EZH2Single nucleotide variant (SNV) or Indel
FOXL2Single nucleotide variant (SNV) or Indel
GNA11Single nucleotide variant (SNV) or Indel
GNAQSingle nucleotide variant (SNV) or Indel
H3F3ASingle nucleotide variant (SNV) or Indel
HNF1ASingle nucleotide variant (SNV) or Indel
HRASSingle nucleotide variant (SNV) or Indel
IDH1Single nucleotide variant (SNV) or Indel
IDH2Single nucleotide variant (SNV) or Indel
MAP2K1Single nucleotide variant (SNV) or Indel
MLH1Single nucleotide variant (SNV) or Indel
MPLSingle nucleotide variant (SNV) or Indel
NPM1Single nucleotide variant (SNV) or Indel
PTPN11Single nucleotide variant (SNV) or Indel
RHOASingle nucleotide variant (SNV) or Indel
ROS1Single nucleotide variant (SNV) or Indel
SRCSingle nucleotide variant (SNV) or Indel
TERTSingle nucleotide variant (SNV) or Indel
ABL1Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
ALKSingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
APCSingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
ATMSingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
AURKASingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
CCNE1Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
CDH1Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
CDK4Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
CDKN2ASingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
DDR2Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
EGFRSingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
ERBB2Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
ERBB3Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
ERBB4Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
FBXW7Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
FGFR1Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
FGFR2Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
FGFR3Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
FLT3Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
GNASSingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
JAK2Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
JAK3Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
KDRSingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
KITSingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
KRASSingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
METSingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
NOTCH1Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
NRASSingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
PDGFRASingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
PIK3CASingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
PIK3R1Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
PTENSingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
RB1Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
RETSingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
SMAD4Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
SMARCB1Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
SMOSingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
STK11Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
TP53Single nucleotide variant (SNV) or IndelCopy number variation (CNV)
VHLSingle nucleotide variant (SNV) or IndelCopy number variation (CNV)
AKT1Single nucleotide variant (SNV) or Indel
ALKSingle nucleotide variant (SNV) or Indel
ARSingle nucleotide variant (SNV) or Indel
BRAFSingle nucleotide variant (SNV) or Indel
CTNNB1Single nucleotide variant (SNV) or Indel
DDR2Single nucleotide variant (SNV) or Indel
EGFRSingle nucleotide variant (SNV) or Indel
ERBB2Single nucleotide variant (SNV) or Indel
ESR1Single nucleotide variant (SNV) or Indel
FGFR1Single nucleotide variant (SNV) or Indel
HRASSingle nucleotide variant (SNV) or Indel
IDH1Single nucleotide variant (SNV) or Indel
IDH2Single nucleotide variant (SNV) or Indel
KITSingle nucleotide variant (SNV) or Indel
KRASSingle nucleotide variant (SNV) or Indel
MAP2K1Single nucleotide variant (SNV) or Indel
MAP2K2Single nucleotide variant (SNV) or Indel
METSingle nucleotide variant (SNV) or Indel
MTORSingle nucleotide variant (SNV) or Indel
NRASSingle nucleotide variant (SNV) or Indel
NTRK1Single nucleotide variant (SNV) or Indel
NTRK3Single nucleotide variant (SNV) or Indel
PDGFRASingle nucleotide variant (SNV) or Indel
PIK3CASingle nucleotide variant (SNV) or Indel
RETSingle nucleotide variant (SNV) or Indel
ROS1Single nucleotide variant (SNV) or Indel
SMAD4Single nucleotide variant (SNV) or Indel
TP53Single nucleotide variant (SNV) or Indel

Legend:

  • Single nucleotide variant (SNV)/Indel SNV/Indel
  • Expression Expression
  • Fusion Fusion, splicing or exon-skipping
  • Internal tandem duplication (ITD) Internal tandem duplication (ITD)
  • Copy number variation (CNV) CNV


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Additional product information

ALK, RET & ROS1 gene fusion map

Archer ALK RET ROS1 v2 Kit Gene Fusions

Talk: Gene fusion detection in FFPE tumors by NGS
 

Lung cancer

Lung cancer is the most deadly form of cancer and the second most-diagnosed cancer in the United States (1). The major types of lung cancer are non-small cell lung cancer and small cell lung cancer.

US cancer incidence and mortality rates by site, 2018

Lung cancer is estimated to have the highest mortality rate and second highest incidence rate per year in the United States (1).

NSCLC

Non-small cell lung cancer (NSCLC) is much more common than small cell lung cancer, accounting for 85% of all lung cancer cases (2). The survival rate for NSCLC cases varies based on the stage at diagnosis, but the average 5-year survival rate is 15.7% (3). Although NSCLC is often associated with smoking, the subtype is also the most common form in non-smokers and can be attributed to genetic alterations, including single nucleotide polymorphisms (SNPs) and fusion mutations (4, 5).

NSCLC is stratified into 3 subtypes based on phenotypic and genotypic differentiation (2, 6).

Adenocarcinoma is the most common form of NSCLC (40% of lung cancers) (5). Like all lung cancers, this subtype is often linked to smoking, although it is not uncommon for non-smokers to develop this subtype of the disease. Gene fusions associated with NSCLC include but are not limited to ALK, RET, ROS1, FGFR3 and NTRK1. Alternative c-MET splicing leading to exon 14 skipping has also been demonstrated to be oncogenic in adenocarcinomas (7).

Squamous cell carcinoma makes up 25-30% of all lung cancers and is usually linked to smoking (5). FGFR3 mutations have been detected in this NSCLC type (8).

Large cell carcinoma comprises 10-15% of lung cancers (5).

Other types of lung cancer include small cell lung cancer and large carcinoid tumor cancer, making up 10-15% and less than 5% of lung cancers, respectively. They also vary in their rate of progression to metastatic disease, with the former spreading quickly and the latter spreading slowly (5).

Lung cancer subtypes

The FusionPlex Lung Kit includes primers to detect the following lung cancer-associated targets:

ALK

ALK fusions predominate the list of lung cancer-associated fusions. In clinical trials, patients that harbored these fusions displayed greater than 60% radiographic response rate when treated with the tyrosine kinase inhibitor (TKI) crizotinib (9). Also, progression-free survival with crizotinib treatment exceeded that of the standard chemotherapy treatment (7.7 months vs. 3.0 months, respectively) (10).  More on ALK, RET & ROS1

RET

RET rearrangements have been reported to convey some level of responsiveness to TKI (cabozantinib) therapy (13). In in vitro models with KIF5B-RET fusions, vandetanib inhibited cell proliferation (14).

In an initial report from a phase II trial with a RET TKI and with prospective RET testing, RET fusion positivity conveyed partial response or disease control with cabozantinib (13, 14). In the clinic, KIF5B-RET fusion-positive lung adenocarcinomas were responsive to vandetanib (15).  More on ALK, RET & ROS1

ROS1

Oncogenic ROS1 rearrangements tend to strike significantly younger patients and is more likely with those who have not smoked (11). In a phase I trial, ROS1-positive NSCLC cases treated with crizotinib exhibited a 72% response rate (12).  More on ALK, RET & ROS1

FGFR3

Recent work analyzing 576 adenocarcinomas found the FGFR3-TACC2 fusion in a subset (0.5%) of the samples (8). FGF receptors are currently a popular target in drug discovery and development, and FGFR3 fusions have been suggested for targeting using FGFR inhibitors in clinical trials (8).  More on FGFR

NTRK1

A recent study reported that 3 out of 91 (3.3%) of adenocarcinomas carried NTRK1 fusions. In pre-clinical in vitro studies, NTRK1 inhibition causes growth inhibition in a NTRK-fusion positive cell line. In the clinic, crizotinib treatment showed limited efficacy (16).  More on NTRK

MET

The c-Met receptor tyrosine kinase is involved in tumorigenesis, cell motility, scattering, invasion and metastasis and has been implicated in small cell lung cancer. Somatic rearrangements have been shown to lead to mutations resulting in the loss of the entire juxtamembrane domain (exon 14) of c-MET (17).  More on MET

References

  1. American Cancer Society: Cancer Facts and Figures 2018. Atlanta, Ga: American Cancer Society, 2018. Last accessed February 26, 2018.
  2. R. S. Herbst, J. V. Heymach, S. M. Lippman, Lung cancer. N. Engl. J. Med. 359, 1367–1380 (2008).
  3. S. F. Altekruse, SEER Cancer Statistics Review, 1975-2007, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2007/, based on November 2009 SEER data submission, posted to the SEER web site, 2010.
  4. Y. S. Ju et al., A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing. Genome Res. 22, 436–445 (2012).
  5. American Cancer Society, What is non-small cell lung cancer, (available at http://www.cancer.org/cancer/lungcancer-non-smallcell
    /detailedguide/non-small-cell-lung-cancer-what-is-non-small-cell-lung-cancer
    ).
  6. W. D. Travis et al., Histological Typing of Lung and Pleural Tumours (Springer Science & Business Media, Berlin, Heidelberg, 1999).
  7. M. Kong-Beltran et al., Somatic mutations lead to an oncogenic deletion of met in lung cancer. Cancer Res. 66, 283–289 (2006).
  8. M. Capelletti et al., Identification of recurrent FGFR3-TACC3 fusion oncogenes from lung adenocarcinoma. Clinical Cancer Research. 20, 6551–6558 (2014).
  9. D. R. Camidge et al., Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study. Lancet Oncol. 13, 1011–1019 (2012).
  10. A. T. Shaw et al., Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N. Engl. J. Med. 368, 2385–2394 (2013).
  11. K. Bergethon et al., ROS1 rearrangements define a unique molecular class of lung cancers. J. Clin. Oncol. 30, 863–870 (2012).
  12. A. T. Shaw et al., Crizotinib in ROS1-rearranged non-small-cell lung cancer. N. Engl. J. Med. 371, 1963–1971 (2014).
  13. A. Drilon et al., Response to Cabozantinib in patients with RET fusion-positive lung adenocarcinomas. Cancer Discovery. 3, 630–635 (2013).
  14. K. Takeuchi et al., RET, ROS1 and ALK fusions in lung cancer. Nature Medicine. 18, 378–381 (2012).
  15. O. Gautschi et al., A patient with lung adenocarcinoma and RET fusion treated with vandetanib. J Thorac Oncol. 8, e43–4 (2013).
  16. A. Vaishnavi et al., Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer. Nature Medicine. 19, 1469–1472 (2013).
  17. P. C. Ma et al., c-MET mutational analysis in small cell lung cancer: novel juxtamembrane domain mutations regulating cytoskeletal functions. Cancer Res. 63, 6272–6281 (2003).

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For Research Use Only. Not for use in diagnostic procedures. For Research Use Only. Not for use in diagnostic procedures.