Heme v2


The Archer® FusionPlex Heme v2 panel is an ribonucleic acid (RNA)-based targeted sequencing test that detects and identifies fusions of 87 genes associated with hematological malignancies. Using Archer’s proprietary Anchored Multiplex PCR (AMP™)-based enrichment, fusions of all genes in this panel can be identified in a single sequencing test, even without prior knowledge of fusion partners or breakpoints. Additionally, select genes are targeted for molecular barcode-enabled relative expression level detection and point mutation coverage.
Key Features
Comprehensive fusion detection

Covers all myeloid- and lymphoid-origin malignancies.

Efficient, lyophilized workflow

Relevant point mutations are built into the panel to maximize the information obtained from your RNA sample.

Expression profiling

Molecular barcode-enabled relative expression level detection in select genes.

Confirm fusion events

Expression imbalance confirmation for most common fusion verification.

Sample versatility

Wide sample type compatibility, including FFPE, blood and bone marrow.

Specifications and Performance

87

Gene Targets

> 10ng

Input Nucleic Acid Required*

> 90%

Unique Molecular On-Target %

2.5 hours

Hands-on Time

9 hours

Total Time

Illumina and
Ion Torrent

Platform

Blood, Fresh Frozen, FFPE

Sample Types

*Input recommendations for FFPE samples vary depending on Archer PreSeq® RNA QC score; 50ng input recommended in absence of PreSeq screening

Gene Targets

LEGEND

SNV/Indel
Expression
Fusion, splicing or exon-skipping

Note: Fusions involving BCR and TCR loci, including IGH, IGL and IGK, are targeted for expression and may not be explicitly called as a fusion because these often do not result in chimeric transcripts.

NeeD to Modify Your Panel?

Add any of our wet lab-validated designs to this panel with Archer Assay Designer to build an assay that fits your exact requirements.

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