Liquid Biopsy Tests

The Archer® LiquidPlex RUO panel for Illumina® is an advanced and user-friendly solution for targeted next-generation sequencing (NGS) of circulating cell-free tumor DNA (ccfDNA/cfDNA/ctDNA) from 28 genes commonly associated with solid tumor type cancers.

Key Features
Specifications
Gene Targets
Additional Resources
Assays

Relevant Fragment Capture

Anchored Multiplex PCR (AMP™)-based target enrichment preferentially enriches for highly fragmented ctDNA over high molecular weight genomic DNA to reduce background and increase detection sensitivity of low-allele fraction (AF) mutations.

Single-Day Library Prep

NGS-ready libraries can be prepared in under 8 hours with less than 1 hour of hands-on time, providing sequencing results in as little as 3 days.

Error Correction & Quantitative Analysis

Molecular barcode sequences ligated prior to amplification enable duplicate read binning and advanced error correction for confident variant calls.

Sensitive & Specific Variant Detection

Reliably detect high AF (5%) variants using as little as 5ng total cfDNA input and low AF (1%) variants from as little as 10ng.

28

Gene Targets

> 5ng

Input cfDNA Required

100%

Target Bases Covered

> 90%

Raw Molecular On-Target

1 Hour

Hands-On Time

1 Day

Total Time

Illumina

Platform

Fusion, splicing or exon-skipping Expression SNV/Indel

Notes

Fusions involving BCR and TCR loci, including IGH, IGL and IGK, are targeted for expression and may not be explicitly called as a fusion because these often do not result in chimeric transcripts
Targets are listed for primary purpose but may detect other mutation types
ABC and GCB DLBCL signature genes are targeted for expression. An experimental classification tool for ABC/GCB differentiation is available in Archer Analysis

TNFRSF13B
AKT1
ALK
AR
BRAF
CTNNB1
DDR2
EGFR
ERBB2
ESR1
FGFR1
HRAS
DH1
IDH2
KIT
KRAS
MAP2K1
MAP2K2
MET
MTOR
NRAS
NTRK1
NTRK3
PDGFRA
PIK3CA
RET
ROS1
SMAD4
TPS3
TNFSF13B
TNFRSF13B
TNFRSF13B

Add any of our wet lab-validated designs to this panel with Archer Assay Designer to build an assay that fits your exact requirements.

Learn More

RNA Input

Input

Reads

Genes

FusionPlex Pane Heme

RNA

4.5M

199

FusionPlex Lung

RNA

500K

FusionPlex Solid Tumor

RNA

DNA Input

Input

Reads

Genes

VariantPlex Solid Tumor

DNA

2.5M

VariantPlex Thyroid and Lung

DNA

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