Liquid Biopsy Tests

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The Archer® LiquidPlex RUO panel for Illumina® is an advanced and user-friendly solution for targeted next-generation sequencing (NGS) of circulating cell-free tumor DNA (ccfDNA/cfDNA/ctDNA) from 28 genes commonly associated with solid tumor type cancers.

  • Key Features
  • Specifications
  • Gene Targets
  • Additional Resources
  • Assays
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Relevant Fragment Capture

Anchored Multiplex PCR (AMP™)-based target enrichment preferentially enriches for highly fragmented ctDNA over high molecular weight genomic DNA to reduce background and increase detection sensitivity of low-allele fraction (AF) mutations.

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Single-Day Library Prep

NGS-ready libraries can be prepared in under 8 hours with less than 1 hour of hands-on time, providing sequencing results in as little as 3 days.

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Error Correction & Quantitative Analysis

Molecular barcode sequences ligated prior to amplification enable duplicate read binning and advanced error correction for confident variant calls.

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Sensitive & Specific Variant Detection

Reliably detect high AF (5%) variants using as little as 5ng total cfDNA input and low AF (1%) variants from as little as 10ng.

28
Gene Targets
> 5ng
Input cfDNA Required
100%
Target Bases Covered
> 90%
Raw Molecular On-Target
1 Hour
Hands-On Time
1 Day
Total Time
Illumina
Platform

Fusion, splicing or exon-skipping Expression SNV/Indel

  • Fusions involving BCR and TCR loci, including IGH, IGL and IGK, are targeted for expression and may not be explicitly called as a fusion because these often do not result in chimeric transcripts
  • Targets are listed for primary purpose but may detect other mutation types
  • ABC and GCB DLBCL signature genes are targeted for expression. An experimental classification tool for ABC/GCB differentiation is available in Archer Analysis
  • TNFRSF13B
  • AKT1
  • ALK
  • AR
  • BRAF
  • CTNNB1
  • DDR2
  • EGFR
  • ERBB2
  • ESR1
  • FGFR1
  • HRAS
  • DH1
  • IDH2
  • KIT
  • KRAS
  • MAP2K1
  • MAP2K2
  • MET
  • MTOR
  • NRAS
  • NTRK1
  • NTRK3
  • PDGFRA
  • PIK3CA
  • RET
  • ROS1
  • SMAD4
  • TPS3
  • TNFSF13B
  • TNFRSF13B
  • TNFRSF13B
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Add any of our wet lab-validated designs to this panel with Archer Assay Designer to build an assay that fits your exact requirements.
RNA Input
Input
Reads
Genes
FusionPlex Pane Heme
RNA
4.5M
199
FusionPlex Lung
RNA
500K
14
FusionPlex Solid Tumor
RNA
1M
31
DNA Input
Input
Reads
Genes
VariantPlex Solid Tumor
DNA
2.5M
67
VariantPlex Thyroid and Lung
DNA
3M
53

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For Research Use Only. Not for use in diagnostic procedures.

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