Lymphoma


The Archer® FusionPlex Lymphoma panel is a targeted next-generation sequencing (NGS) test to simultaneously detect and identify fusions, point mutations, and expression levels in 125 genes linked to lymphomas. Using Anchored Multiplex PCR (AMP™)-based enrichment, fusions can be identified even without prior knowledge of fusion partners or breakpoints. Additionally, select genes are targeted for molecular barcode-enabled relative expression detection and coverage over key hotspot regions.
Key Features
Comprehensive fusion detection

Detect known and novel fusions associated with lymphomas.

Efficient, lyophilized workflow

Relevant point mutations are built into the panel to maximize the information obtained from your RNA sample.

Expression profiling

Molecular barcode-enabled relative expression detection in genes relevant for GCB vs. ABC DLBCL distinction and immune checkpoint markers.

Sample versatility

Wide sample type compatibility, including FFPE, blood and bone marrow.

Specifications and Performance

125

Gene Targets

> 10ng

Input Nucleic Acid Required*

> 90%

Unique Molecular On-Target %

2.5 hours

Hands-on Time

9 hours

Total Time

Illumina and
Ion Torrent

Platform

Blood, Fresh Frozen, FFPE

Sample Types

*Input recommendations for FFPE samples vary depending on Archer PreSeq® RNA QC score; 50ng input recommended in absence of PreSeq screening

Gene Targets

LEGEND

SNV/Indel
Expression
Fusion, splicing or exon-skipping

Notes

  • Fusions involving BCR and TCR loci, including IGH, IGL and IGK, are targeted for expression and may not be explicitly called as a fusion because these often do not result in chimeric transcripts
  • Targets are listed for primary purpose but may detect other mutation types
  • ABC and GCB DLBCL signature genes are targeted for expression. An experimental classification tool for ABC/GCB differentiation is available in Archer Analysis
NeeD to Modify Your Panel?

Add any of our wet lab-validated designs to this panel with Archer Assay Designer to build an assay that fits your exact requirements.

  • Find Your Fit

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