Myeloid


The Archer® VariantPlex myeloid panel is a 75-gene targeted sequencing panel for acute myeloid leukemia (AML), myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS) and some lymphoid malignancy markers. Powered by Anchored Multiplex PCR (AMP™) chemistry, the panel enables deep strand-specific amplification of molecular barcoded deoxyribonucleic acid (DNA) fragments for sequencing.
Key Features
Confident

Confident and sensitive, unique molecule-driven variant detection.

Robust

Robust FLT3-ITD detection of all sizes and insertion points.

Coverage

Complete coverage, including challenging genes like CEBPA.

Simple

Simple, lyophilized single day library preparation.

Detection

CNV detection for key genes in -7/7q, -5/5q, -13q, -11q, -12p/12p.

Specifications and Performance

75

Gene Targets

~125.4kb

Total Target Size

≥ 10ng

Input DNA Required‡

> 99.8%

Coverage Uniformity > 20% Mean

2.5 hours

Hands-On Time

1 Day

Total Time

Illumina

Platform

Blood, Bone Marrow, PBL, FFPE

Sample Types

†Expected coverage uniformity at the recommended read depth.
‡input recommendations for FFPE samples vary depending on Archer PreSeq® DNA QC score. 50ng input recommended in absence of PreSeq screening

Gene Targets

LEGEND

SNV/Indel
Expression
Fusion, splicing or exon-skipping

NeeD to Modify Your Panel?

Add any of our wet lab-validated designs to this panel with Archer Assay Designer to build an assay that fits your exact requirements.

  • Find Your Fit

Capabilities

AMP-Enabled FLT3-ITD Detection

Independent and bidirectional probes are optimized to detect ITDs of all sizes.The reads originating from these probes are bioinformatically assembled by Archer Analysis to form longer consensus sequences that span the ITD. These longer sequences are then aligned to the reference genome to identify the presence of even very large ITDs.

High-Complexity Coverage Across CEBPA

Complete, strand-specific and bi-directional coverage of target exons, including traditionally difficult regions like CEBPA.

Robust CALR Deletion Detection

Powerful analysis of complex variants like CALR deletions can be detected using Archer Analysis due to the unique benefits of Anchored Multiplex PCR and extensive testing with positive samples and in-silico read generation technology.

Sensitive and Intuitive CNV Detection

Chromosomal arm loss is prevalent in certain myeloid malignancies (e.g., -7/7q, -5/5q, -13q, -11q and -12p/12p). The VariantPlex Myeloid panel targets key genes within these chromosomes to indicate copy loss.

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