Specifications and Performance
Total Target Size
Input DNA Required‡
> 99.8%Coverage Uniformity > 20% Mean†
Blood, Bone Marrow, PBL, FFPE
†Expected coverage uniformity at the recommended read depth.
‡input recommendations for FFPE samples vary depending on Archer PreSeq® DNA QC score. 50ng input recommended in absence of PreSeq screening
AMP-Enabled FLT3-ITD Detection
Independent and bidirectional probes are optimized to detect ITDs of all sizes.The reads originating from these probes are bioinformatically assembled by Archer Analysis to form longer consensus sequences that span the ITD. These longer sequences are then aligned to the reference genome to identify the presence of even very large ITDs.
High-Complexity Coverage Across CEBPA
Complete, strand-specific and bi-directional coverage of target exons, including traditionally difficult regions like CEBPA.
Robust CALR Deletion Detection
Powerful analysis of complex variants like CALR deletions can be detected using Archer Analysis due to the unique benefits of Anchored Multiplex PCR and extensive testing with positive samples and in-silico read generation technology.
Sensitive and Intuitive CNV Detection
Chromosomal arm loss is prevalent in certain myeloid malignancies (e.g., -7/7q, -5/5q, -13q, -11q and -12p/12p). The VariantPlex Myeloid panel targets key genes within these chromosomes to indicate copy loss.