Oncology Research


The Archer® FusionPlex Oncology Research panel is a targeted next-generation sequencing (NGS) test to simultaneously detect and identify fusions and other mutations associated with 75 genes found in ribonucleic acid (RNA) transcripts that are linked to various cancers. This panel is extensive and purpose-built to advance fusion discovery, including research efforts in the area of Ph-like acute lymphoblastic leukemia (ALL) fusions.
Key Features
Comprehensive Fusion Detection

Anchored Multiplex PCR (AMP™) chemistry utilizes open-ended targeted amplification to identify gene fusions whether or not the fusion partner is known.

Splice Variants

Detect cancer-associated isoforms and alternative splicing events.

Low Input

Purpose-built for wide sample type compatibility, including low-input and degraded samples such as FFPE tissue.

simple, lyophilized workflow

Easy-to-handle lyophilized reagents and a simple workflow to minimize errors and reduce turn-around time.

Product Information
Specifications and Performance

75

Gene Targets

> 10ng

Input Nucleic Acid Required*

> 96%

Unique Molecular On-Target %

2.5 hours

Hands-on Time

9 hours

Total Time

Illumina and
Ion Torrent

Platform

Fresh Frozen or FFPE

Sample Types

*Input recommendations for FFPE samples vary depending on Archer PreSeq® RNA QC score; 50ng input recommended in absence of PreSeq screening

Gene Targets

ABL1

ABL2

AKT1

AKT2

AKT3

ALK

ARHGAP26

AXL

BRAF

BRD3

BRD4

CRLF2

CSF1R

EGFR

EPOR

ERBB2

ERBB4

ERG

ESR1

ESRRA

ETV1

ETV4

ETV5

ETV6

EWSR1

FGFR1

FGFR2

FGFR3

FGR

IL2RB

INSR

JAK1

JAK2

JAK3

KIT

MAML2

MAST1

MAST2

MET

MSMB

MUSK

MYB

MYC

NOTCH1

NOTCH2

NRG1

NTRK1

NTRK2

NTRK3

NUMBL

NUT

PDGFRA

PDGFRB

PIK3CA

PKN1

PPARG

PRKCA

PRKCB

PTK2B

RAF1

RARA

RELA

RET

ROS1

RSPO2

RSPO3

SYK

TERT

TFE3

TFEB

THADA

TMPRSS2

TSLP

TYK2

LEGEND

SNV/Indel
Fusion, splicing or exon-skipping

NeeD to Modify Your Panel?

Add any of our wet lab-validated designs to this panel with Archer Assay Designer to build an assay that fits your exact requirements.

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