FusionPlex ALL

Acute Lymphoblastic Leukemia (ALL)

The Archer® FusionPlex Acute Lymphoblastic Leukemia (ALL) panel is a targeted next-generation sequencing (NGS) product to detect and identify fusions, point mutations and expression levels in 81 genes associated with ALL, including all recurrent Ph-like ALL fusion events. The panel uses Archer’s proprietary Anchored Multiplex PCR (AMP™)-based enrichment to detect fusions of all target genes in a single sequencing product, even without prior knowledge of fusion partners or breakpoints. 

  • Key Features
  • Specifications
  • Gene Targets
  • Additional Resources
Comprehensive Fusion Detection

AMP chemistry utilizes open-ended targeted amplification to identify gene fusions whether or not the fusion partner is known.

Splice Variants

Detect cancer-associated isoforms and alternative splicing events.

Low Input

Purpose-built for wide sample type compatibility, including low-input and degraded samples such as FFPE tissue.

Simple, Lyophilized Workflow

Easy-to-handle lyophilized reagents and a simple workflow to minimize errors and reduce turn-around time.

Properties

Specifications

Gene Targets
81
Input Nucleic Acid Required*
≤10ng
Unique Molecular On-Target %
>95%
Hands-On Time
2.5 Hour
Total Time
9 Hours
Platform
Illumina® and Ion Torrent®
Sample Types
Blood, Fresh frozen and FFPE

Input recommendations for FFPE samples vary depending on Archer PreSeq® RNA QC score; 50ng input recommended in absence of PreSeq screening

ABL1

ABL2

AICDA

BCL11B

BCL2

BCL6

BCR

BLNK

DNTT

EBF1

EPOR

ETV6

EZH2

FBXW7

FGFR1

FLT3

HOXA10

HOXA9

IDH1

IDH2

IKZF1

IKZF2

IKZF3

IL7R

IRF4

IRF8

JAK1

JAK2

JAK3

KDM6A

KLF2

KMT2A

KRAS

LMO1

LYL1

MLLT4

MPL

MYC

NF1

NOTCH1

NRAS

NT5C2

NTRK3

NUP214

NUP98

P2RY8

PAG1

PAX5

PBX1

PDCD1

PDCD1LG2

PDGFRA

PDGFRB

PICALM

PTK2B

PTPN11

RAG1

RAG2

RUNX1

SEMA6A

SETD2

SH2B3

SOX11

STAT3

STAT5B

STIL

TAL1

TCF3

TLX1

TLX3

TYK2

WT1

ZCCHC7

CD274

CHD1

CREBBP

CRLF2

CSF1R

CTLA4

DNM2

LEGEND

SNV/Indel
Fusion, splicing or exon-skipping
Expression

Product Information
Illumina
  • AB0013 - 8-reactions
  • AB0065 - 48-reactions
  • AB0035 – 16-reactions – Ask about our starter panel
ION TORRENT™
  • AB0014 - 8-reactions
  • AB0066 - 48-reactions
  • AB0036 – 16-reactions – Ask about our starter panel
Archer Analysis

Need to modify your panel?

Add any of our wet lab-validated designs to this panel with Archer Assay Designer to build an assay that fits your exact requirements.

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For Research Use Only. Not for use in diagnostic procedures.

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For Research Use Only. Not for use in diagnostic procedures.