FusionPlex Myeloid

Myeloid

The Archer® FusionPlex Myeloid panel is a targeted next-generation sequencing (NGS) test to detect and identify fusions, point mutations and expression levels from 84 genes associated with myeloid-origin malignancies. Using Archer’s proprietary Anchored Multiplex PCR (AMP™) based enrichment, fusions of all genes in this panel can be identified in a single sequencing test, even without prior knowledge of fusion partners or breakpoints. Additionally, select genes are targeted for molecular barcode-enabled relative expression level detection and point mutation coverage.

  • Key Features
  • Specifications
  • Gene Targets
  • Additional Resources
Comprehensive Fusion Detection

AMP chemistry utilizes open-ended targeted amplification to identify gene fusions whether or not the fusion partner is known.

Sample Versatility

Wide sample type compatibility, including FFPE or fresh frozen tissue, blood, bone marrow aspirates and cell fractions.

Expression Profiling

Molecular barcoded fragments enable accurate RNA abundance calculations.

Simple, Lyophilized Workflow

Easy-to-handle lyophilized reagents and a simple workflow to minimize errors and reduce turn-around time.

Properties

Specifications

Gene Targets
84
Input Nucleic Acid Required*
≤10ng
Unique Molecular On-Target %
>96%
Hands-on Time
2.5 hours
Total Time
9 hours
Platform
Illumina® and Ion Torrent®
Sample Types
Blood, Fresh frozen and FFPE

Input recommendations for FFPE samples vary depending on Archer PreSeq® RNA QC score; 50ng input recommended in absence of PreSeq screening

ABL1

AKT3

ASXL1

BCR

BRAF

CALR

CBFB

CBL

CD274

CEBPA

CHD1

CHIC2

CREBBP

CSF1R

CSF3R

CTLA4

DCK

DNM2

DNMT3A

ERG

ETV6

EZH2

FBXW7

FGFR1

FGFR2

FGFR3

FLT3

GATA1

GATA2

GLIS2

GNAS

ID4

IDH1

IDH2

IKZF1

IKZF3

IRF4

IRF8

JAK1

JAK2

JAK3

KAT6A

KDM6A

KIT

KMT2A

KRAS

MECOM

MKL1

MLLT10

MLLT4

MPL

MUC1

MYC

MYD88

MYH11

NF1

NOTCH1

NPM1

NRAS

NUP214

NUP98

PDCD1

PDCD1LG2

PDGFRA

PDGFRB

PHF6

PICALM

PML

PTPN11

RARA

RBM15

ROS1

RUNX1

RUNX1T1

SETBP1

SETD2

SF3B1

SLC29A1

SRSF2

TCF3

TFG

U2AF1

WT1

XPO1

LEGEND

SNV/Indel
Fusion, splicing or exon-skipping
Expression

Product Information
ILLUMINA®
  • AB0015 - 8-reactions
  • AB0067 - 48-reactions
  • AB0037 – 16-reactions – Ask about our starter panel
ION TORRENT™
  • AB0016 - 8-reactions
  • AB0068 - 48-reactions
  • AB0038 – 16-reactions – Ask about our starter panel
Archer® Analysis

Need to modify your panel?

Add any of our wet lab-validated designs to this panel with Archer Assay Designer to build an assay that fits your exact requirements.

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For Research Use Only. Not for use in diagnostic procedures.

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For Research Use Only. Not for use in diagnostic procedures.