Core Myeloid

The VariantPlex Core Myeloid panel is next-generation targeted sequencing (NGS) product for acute myeloid leukemia (AML), myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS) and some lymphoid malignancy markers. Powered by Anchored Multiplex PCR (AMP™) chemistry, the panel enables deep strand-specific amplification of molecular barcoded DNA fragments for sequencing.

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Complex Variant Detection

Coverage combined with powerful bioinformatics enable variant detection in traditionally difficult regions like CEBPA & FLT3.

Low Input

AMP chemistry was purpose-built for wide sample compatibility, including low-input and degraded samples such as FFPE tissue.

Quantitative CNV Detection

Molecular barcoded fragments counting provides robust copy number analysis.

Simple, Lyophilized Workflow

Easy-to-handle lyophilized reagents and a simple workflow to minimize errors and reduce turn-around time.

Properties

Specifications

Gene Targets

37 Input DNA Required*

≤10ng

Coverage Uniformity >20% Mean+

>99.8%

Hands-on Time

2.5 hours

Total Time

1 Day

Platform

Illumina®

Sample Types

Blood, Bone Marrow, PBL and FFPE

+Expected coverage uniformity at the recommended read depth. *Input recommendations for FFPE samples vary depending on PreSeq® RNA QC score; 50ng input recommended in absence of PreSeq screening