VariantPlex Core Myeloid

Core Myeloid

The Archer® VariantPlex Core Myeloid panel is next-generation targeted sequencing (NGS) product for acute myeloid leukemia (AML), myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS) and some lymphoid malignancy markers. Powered by Anchored Multiplex PCR (AMP™) chemistry, the panel enables deep strand-specific amplification of molecular barcoded DNA fragments for sequencing.

  • Key Features
  • Specifications
  • Gene Targets
  • Additional Resources
Complex Variant Detection

Coverage combined with powerful bioinformatics enable variant detection in traditionally difficult regions like CEBPA & FLT3.

Low Input

AMP chemistry was purpose-built for wide sample compatibility, including low-input and degraded samples such as FFPE tissue.

Quantitative CNV Detection

Molecular barcoded fragments counting provides robust copy number analysis.

Simple, Lyophilized Workflow

Easy-to-handle lyophilized reagents and a simple workflow to minimize errors and reduce turn-around time.

Properties

Specifications

Gene Targets
37
Input DNA Required*
≤10ng
Coverage Uniformity >20% Mean+
>99.8%
Hands-on Time
2.5 hours
Total Time
1 Day
Platform
Illumina®
Sample Types
Blood, Bone Marrow, PBL and FFPE

+Expected coverage uniformity at the recommended read depth. *Input recommendations for FFPE samples vary depending on Archer PreSeq® RNA QC score; 50ng input recommended in absence of PreSeq screening

ABL1

ANKRD26

ASXL1

BCOR

BRAF

CALR

CBL

CEBPA

CSF3R

DDX41

DNMT3A

ETNK1

ETV6

EZH2

FLT3

GATA1

GATA2

IDH1

IDH2

JAK2

KIT

KRAS

MPL

NPM1

NRAS

PHF6

PTPN11

RUNX1

SETBP1

SF3B1

SRSF2

STAG2

TET2

TP53

U2AF1

WT1

ZRSR2

LEGEND

   SNV/Indel
   CNV
   Internal tandem duplication (ITD)

Product Information
ILLUMINA®
  • AB0100 - 8-reactions
  • AB0102 - 48-reactions
  • AB0101 – 16-reactions – Ask about our starter panel
Archer® Analysis

Need to modify your panel?

Add any of our wet lab-validated designs to this panel with Archer Assay Designer to build an assay that fits your exact requirements.

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For Research Use Only. Not for use in diagnostic procedures.

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For Research Use Only. Not for use in diagnostic procedures.