ctDNA 28
Liquid Biopsy Research
The LiquidPlex RUO panel for Illumina® is an advanced and user-friendly solution for targeted next-generation sequencing (NGS) of circulating cell-free tumor DNA (ccfDNA/cfDNA/ctDNA) from 28 genes commonly associated with solid tumor type cancers.
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- Key Features
- Specifications
- Gene Targets
- Additional Resources
Relevant Fragment Capture
Anchored Multiplex PCR (AMP™)-based target enrichment preferentially enriches for highly fragmented ctDNA over high molecular weight genomic DNA to reduce background and increase detection sensitivity of low-allele fraction (AF) mutations.
Single-day library prep
NGS-ready libraries can be prepared in under 8 hours with 2.5 hours of hands-on time, providing sequencing results in as little as 3 days.
Error correction & Quantitative Analysis
Molecular barcode sequences ligated prior to amplification enable duplicate read binning and advanced error correction for confident variant calls.
Sensitive & Specific Variant Detection
Reliably detect high AF (5%) variants using as little as 5ng total cfDNA input and low AF (1%) variants from as little as 10ng
Properties
Specifications
Gene Targets
28
Input DNA Required
≤5ng
Target Bases Covered
100%
Hands-On Time
2.5 Hours
Total Time
1 Day
Platform
Illumina
Raw Molecular On-Target
>90%
AKT1
ALK
AR
BRAF
CTNNB1
DDR2
EGFR
ERBB2
ESR1
FGFR1
HRAS
IDH1
IDH2
KIT
KRAS
MAP2K1
MAP2K2
MET
MTOR
NRAS
NTRK1
NTRK3
PDGFRA
PIK3CA
RET
ROS1
SMAD4
TP53
LEGEND
SNV/Indel
Product Information
Illumina®
- AB0088 - 8-reactions
- AB0089 - 16-reactions Learn More
- Download Protocol
Archer® Analysis
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