Expanded Solid Tumor
The VariantPlex Expanded Solid Tumor panel is a targeted next-generation sequencing (NGS) assay that simultaneously detects and characterizes copy number variations (CNVs), single-nucleotide variants (SNVs), insertions and deletions (indels), and microsatellite instability (MSI) status in 76 cancer-implicated genes, including non-small cell lung cancer, colorectal cancer, breast cancer, bladder cancer, pancreatic cancer, prostate cancer, cholangiocarcinoma and melanoma. Thoughtfully designed based on guidelines, literature, and customer input, this recently expanded panel offers sensitive variant detection even with low sample input.
Invitae’s unique outlier detection algorithm leverages position-specific data to enable confident reporting at low allele frequencies.
Create from scratch or modify any panel to keep up with the pace of discovery.
Anchored Multiplex PCR (AMP™) chemistry was purpose-built for wide sample type compatibility, including low-input and degraded samples such as FFPE tissue.
Simple, Lyophilized Workflow
Easy-to-handle lyophilized reagents and a simple workflow to reduce turnaround time, as well as minimize errors and contamination risk.
76 + MSI
Input DNA Required*
Recommended # of reads
FFPE, fresh frozen, cytology smear, FNA
*Input mass requirements vary depending on type and quality. Unless the tumor cellularity and sample quality are high, 50ng of FFPE-derived nucleic acid should be considered the minimum recommendation. If input is not limiting, 200ng is recommended.