Sarcoma


The Archer® FusionPlex Sarcoma panel is a targeted sequencing test to simultaneously detect and identify fusions of 26 genes associated with soft tissue cancers. Using Archer’s proprietary Anchored Multiplex PCR (AMP™)-based enrichment, fusions of all genes in this panel can be identified in a single sequencing test, even without prior knowledge of fusion partners or breakpoints.
Key Features
Comprehensive Fusion Detection

AMP chemistry utilizes open-ended targeted amplification to identify gene fusions whether or not the fusion partner is known.

Low Input

Purpose-built for wide sample type compatibility, including low-input and degraded samples such as FFPE tissue.

Quiver® Fusion Database

Powerful fusion analysis combined with a curated database of relevant known translocations.

Simple, Lyophilized Workflow

Easy-to-handle lyophilized reagents and a simple workflow to minimize errors and reduce turn-around time.

Product Information
Specifications and Performance

26

Gene Targets

> 10ng

Input Nucleic Acid Required*

> 95%

Unique Molecular On-Target %

2.5 hours

Hands-on Time

9 hours

Total Time

Illumina and
Ion Torrent

Platform

Fresh Frozen or FFPE

Sample Types

*Input recommendations for FFPE samples vary depending on Archer PreSeq® RNA QC score; 50ng input recommended in absence of PreSeq screening

Gene Targets

ALK

CAMTA1

CCNB3

CIC

EPC1

EWSR1

FOXO1

FUS

GLI1

HMGA2

JAZF1

MEAF6

MKL2

NCOA2

NTRK3

PDGFB

PLAG1

ROS1

SS18

STAT6

TAF15

TCF12

TFE3

TFG

USP6

YWHAE

LEGEND

Fusion, splicing or exon-skipping

NeeD to Modify Your Panel?

Add any of our wet lab-validated designs to this panel with Archer Assay Designer to build an assay that fits your exact requirements.

  • Find Your Fit

LiquidPlex Concordance Panel

Now you can do paired multiplex analysis of FFPE and liquid biopsy samples.

The Archer LiquidPlex Concordance panel combines Archer VariantPlex® with LiquidPlex for powerful copy number and variant detection from solid tumors and sensitive mutation detection from ctDNA, respectively. The panel also includes the Archer PreSeq® DNA QC Assay to prescreen DNA FFPE samples prior to library prep.

Concordance Panel Contents:

  • LiquidPlex reagents, 16 reactions
  • VariantPlex reagents, 16 reactions
  • Gene-specific primers, 32 reactions
  • PreSeq DNA QC Assay, 16 reactions

Detecting fusions using the Archer FusionPlex Sarcoma Panel

ArcherDX, Inc. has developed a panel for the rapid detection of sarcoma-associated translocations from total nucleic acid isolated from tumor samples—including FFPE preserved specimens. Anchored Multiplex PCR (AMP) enables rapid preparation of highly multiplexed next-generation sequencing (NGS) libraries for targeted capture of mRNAs produced from fusion genes. The Archer technology permits the simultaneous detection of both known recurrent fusions as well as previously unidentified fusions at key breakpoints in target genes. Archer’s Sarcoma panel offers a complete fusion detection solution, from library preparation through data analysis, for both the Illumina and Ion Torrent platforms.

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