Internal cross verification
Detecting somatic mutations in RNA, DNA and ctDNA provides internal cross verification. Not only can fusions be verified by a detected expression imbalance, but CNVs and expression profiles can verify or classify oncogenic mechanisms. Also, SNVs found in both RNA and DNA can confirm the presence of the mutation, expression and potential allelic imbalance. Concordance studies have never been so powerful and easy to perform.
Solid Tumor Panels