Tech Notes

Archer Analysis expresses LOD as the minimum allele fraction at which a variant can be distinguished from underlying noise at a statistical power of 0.95, referred to as 95 MDAF. This enables precise detection of sensitivity at each base position.

Six popular commercially-available FFPE extraction panels are tested for performance in conjunction with Anchored Multiplex PCR (AMP™) chemistry.

FLT3 encodes a receptor tyrosine kinase that is involved in p53 activation and has roles in cell growth arrest and apoptosis. Internal tandem duplications (ITDs) in the juxtamembrane domain result in constitutive activation of FLT3, causing aberrant cell growth leading to tumorigenesis. FLT3-ITDs are associated with poor prognosis of acute myeloid leukemia (AML) and are detected in about 25% of AML cases. As FLT3-ITD expressed kinases are sensitive to tyrosine kinase inhibitors, they are of considerable interest for the development of novel AML treatments.

Sample barcoding, also called sample indexing, is a common approach to labeling samples for multiplex sequencing and analysis. All nucleic acids in a sample are labeled with the same sequence tag, and the result- ing library is pooled with other libraries and sequenced in parallel in a single run. Then, during analysis, the sample-speci c indexes enable the software to sepa- rate the multiplexed sequence data in sample-speci c data sets

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