Comprehensive Thyroid and Lung


The Archer® VariantPlex Comprehensive Thyroid and Lung (CTL) panel is an next-generation sequencing (NGS)-based targeted sequencing test to detect copy number variations (CNVs), single-nucleotide variants (SNVs) and indels in 31 thyroid and lung cancer-implicated genes. The panel covers entire targeted exons while maintaining high coverage uniformity (> 95%) and on-target reads (99.9%). When used alongside the ribonucleic acid (RNA)-based FusionPlex® CTL panel, fusions, SNVs, CNVs and expression profiles can be analyzed from a single low-input FFPE sample.
Key Features
Expert primer design

Includes intronic buffers, complete target region coverage and high coverage uniformity.

Orthogonal validation

Confirm relevant CNV and SNV calls when using the companion FusionPlex CTL panel.

Purpose-built

Optimized for low-input FFPE samples from fine needle aspirates (FNAs).

Molecular barcodes

Enable accurate CNV detection in relevant targets.

Specifications and Performance

31

Gene Targets

~21.6kb

Total Target Size

> 10ng

Input DNA Required

> 97%

Coverage Uniformity > 20% Mean†

2.5 hours

Hands-on Time

1 Day

Total Time

Illumina

Platform

Fresh Frozen or FFPE

Sample Types

†Expected coverage uniformity at the recommended read depth.
‡input recommendations for FFPE samples vary depending on Archer PreSeq® DNA QC score. 50ng input recommended in absence of PreSeq screening

Gene Targets

LEGEND

SNV/Indel
CNV

NeeD to Modify Your Panel?

Add any of our wet lab-validated designs to this panel with Archer Assay Designer to build an assay that fits your exact requirements.

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