Video Library


Workshop: AML mutation detection using error-corrected sequencing

  • Published on Friday, November 30, 2018
Acute myeloid leukemia (AML) is a clonally heterogeneous cancer where the landscape of mutations is highly variable between children and adults, involving complex chromosomal translocations, indels and single nucleotide variants (SNVs). Traditional molecular assays rely upon multiple platforms to identify mutations but generally lack quantitation of rare clones. Advances in sequencing-based methods enable comprehensive detection of gene fusions, SNVs, gene expression and internal tandem duplications. In this workshop, Dr. Todd Druley from Washington University describes his use of error-corrected sequencing coupled with powerful bioinformatics to detect rare clonal variants in adult and pediatric AML.


Workshop: Implementing NGS to quantify human and pathogen tumor markers in plasma and tissue

  • Published on Thursday, November 29, 2018
Margaret Gulley, MD from the UNC School of Medicine describes her group’s method to quantify cancer mutations alongside tumor-related viral and bacterial pathogens in plasma and FFPE tissue using modified off-the-shelf Archer NGS reagents combined with Archer Analysis bioinformatics. She will discuss analytic and clinical interpretation criteria and the value of molecular barcodes and noise reduction algorithms in patient and control DNA.


Webinar: Validation of Error-Corrected Sequencing for Hematological Malignancies

  • Published on Thursday, October 18, 2018
In this webinar, Drs. Catherine Rehder and Sarah Rapisardo at Duke University describes their efforts to validate the Archer® VariantPlex® Myeloid assay. They also discuss their work to expand testing with a custom Archer FusionPlex® assay to detect known and novel fusions, with a focus on Ph-like ALL fusions.


Utility of Anchored Multiplex PCR for gene fusion detection

  • Published on Monday, August 27, 2018
Cecilia Yeung, MD. from Fred Hutchinson Cancer Research Center discusses how she is using AMP™ technology for rapid identification of fusions in leukemias with Oxford Nanopore™ real-time sequencing. This webinar was recorded on August 7, 2018.

Get less noise and more signficiance from liquid biopsies with Archer® Reveal ctDNA™. Learn more today.

Plasma Mutation Panel

  • Published on Monday, January 1, 2018
In this AMP 2017 workshop, Dr. Margaret L. Gulley from the UNC School of Medicine describes her ability to confidently detect variants and viral markers in plasma DNA using targeted NGS coupled with powerful bioinformatics.


Get less noise and more signficiance from liquid biopsies with Archer® Reveal ctDNA™. Learn more today.

Archer Reveal ctDNA 28

  • Published on Monday, February 13, 2017
The Archer® Reveal ctDNA™ 28 Kit for Illumina® is an advanced and user-friendly solution for targeted next generation sequencing (NGS) of circulating cell-free tumor DNA (ccfDNA/cfDNA/ctDNA) from 28 genes commonly found mutated in solid tumor type cancers.


FLT3-ITD Detection With Archer® Blood Cancer Assays

  • Published on Friday, August 19, 2016
The molecular landscape of leukemia and lymphoma has expanded exponentially in the last two decades, and the complexity and scope of biomarkers makes molecular analysis difficult for any single approach. Archer FusionPlex and VariantPlex assays are powered by Anchored Multiplex PCR (AMP™) target enrichment chemistry to detect multiple mutation types and gene expression profiling in a single sample.


Why RNA is better for fusion detection

  • Published on Friday, November 13, 2015
Why do Archer FusionPlex™ assays use RNA instead of DNA for input material? It all comes down to biological relevance, cost, and turn-around time. See why RNA is better for fusion detection than DNA-based hybrid capture techniques.


AMP is better: Strand Specificity

  • Published on Thursday, August 13, 2015
See how Anchored Multiplex PCR (AMP™) chemistry is better than traditional opposing primer-based enrichment, because strand-specific priming allows you to identify and correct for deamination events that would otherwise lease to false-positive results.


Comprehensive Tumor Profiling

  • Published on Wednesday, July 29, 2015
Learn how using Archer™ FusionPlex™ RNA assays and VariantPlex™ DNA assays in parallel makes it possible to generate comprehensive target-enriched libraries for next-generation sequencing to detect clinically relevant fusions, CNVs, SNVs and indels.


FusionPlex Anchored Multiplex PCR (AMP) Chemistry

  • Published on Wednesday, July 29, 2015
Learn how the FusionPlex system utilizes Anchored Multiplex PCR chemistry to create target enriched RNA libraries for next-generation sequencing.


VariantPlex Anchored Multiplex PCR (AMP) Chemistry

  • Published on Wednesday, July 29, 2015
Learn how the Archer VariantPlex system uses Anchored Multiplex PCR, which utilizes a combination of gene specific primers and half-functional universal adapters to create target enriched DNA libraries for next generation sequencing.


Learn more about Anchored Multiplex PCR (AMP™) chemistry to detect novel fusions, or go to Archer® FusionPlex® NGS assays to order fusion assays.

AMP is better for novel gene fusion detection

  • Published on Friday, July 17, 2015
Anchored Multiplex PCR enables the detection of targets of interest, including any known or novel fusion partners by using target-specific primers uni-directional primers, along with reverse primers, that hybridize to the sequencing adapter that is ligated to each fragment prior to amplification.


Archer Molecular Barcode Adapters

  • Published on Thursday, March 12, 2015
Archer Anchored Multiplex PCR (AMP) technology utilizes Molecular Barcode (MBC) Adapters for error correction, sample identification, de duplication, and advanced analysis in targeted sequencing NGS applications


Find our fit.
Get true NGS assay customization with Archer® Assay Designer. Learn more today.

Archer FusionPlex Custom Panels Overview

  • Published on Tuesday, March 10, 2015
Use the Archer Assay Designer to create FusionPlex custom panels to detect and characterize specific gene fusions in your samples by next-generation sequencing


Anchored Multiplex PCR chemistry

  • Published on Wednesday, January 21, 2015
Anchored Multiplex PCR (AMP) uses gene-specific primers and half-functional universal adapters to generate DNA libraries that are enriched for specific targets and any unknown fusion partners, which can then be detected by next-generation sequencing.

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All content © 2019 ArcherDX, Inc.

For Research Use Only. Not for use in diagnostic procedures. For Research Use Only. Not for use in diagnostic procedures.