Video Library


Workshop: AML mutation detection using error-corrected sequencing

  • Published on Friday, November 30, 2018
Acute myeloid leukemia (AML) is a clonally heterogeneous cancer where the landscape of mutations is highly variable between children and adults, involving complex chromosomal translocations, indels and single nucleotide variants (SNVs). Traditional molecular assays rely upon multiple platforms to identify mutations but generally lack quantitation of rare clones. Advances in sequencing-based methods enable comprehensive detection of gene fusions, SNVs, gene expression and internal tandem duplications. In this workshop, Dr. Todd Druley from Washington University describes his use of error-corrected sequencing coupled with powerful bioinformatics to detect rare clonal variants in adult and pediatric AML.


Workshop: Implementing NGS to quantify human and pathogen tumor markers in plasma and tissue

  • Published on Thursday, November 29, 2018
Margaret Gulley, MD from the UNC School of Medicine describes her group’s method to quantify cancer mutations alongside tumor-related viral and bacterial pathogens in plasma and FFPE tissue using modified off-the-shelf Archer NGS reagents combined with Archer Analysis bioinformatics. She will discuss analytic and clinical interpretation criteria and the value of molecular barcodes and noise reduction algorithms in patient and control DNA.


Webinar: Validation of Error-Corrected Sequencing for Hematological Malignancies

  • Published on Thursday, October 18, 2018
In this webinar, Drs. Catherine Rehder and Sarah Rapisardo at Duke University describes their efforts to validate the Archer® VariantPlex® Myeloid assay. They also discuss their work to expand testing with a custom Archer FusionPlex® assay to detect known and novel fusions, with a focus on Ph-like ALL fusions.


Utility of Anchored Multiplex PCR for gene fusion detection

  • Published on Monday, August 27, 2018
Cecilia Yeung, MD. from Fred Hutchinson Cancer Research Center discusses how she is using AMP™ technology for rapid identification of fusions in leukemias with Oxford Nanopore™ real-time sequencing. This webinar was recorded on August 7, 2018.

Get less noise and more signficiance from liquid biopsies with Archer® Reveal ctDNA™. Learn more today.

Plasma Mutation Panel

  • Published on Monday, January 1, 2018
In this AMP 2017 workshop, Dr. Margaret L. Gulley from the UNC School of Medicine describes her ability to confidently detect variants and viral markers in plasma DNA using targeted NGS coupled with powerful bioinformatics.


Webinar: The new standard in NGS-based myeloid mutation detection

  • Published on Monday, November 13, 2017
In this webinar, Massachusetts General Hospital pathologist Long Phi Le, MD, PhD, will discuss how updates to the assay and software provide better coverage, lower limits of detection, high-resolution CNV detection and lightning-fast analysis. Brent Lutz, Software Product Manager at ArcherDX, will introduce Dr. Le, as well as review the latest improvements in Archer Analysis.


Get less noise and more signficiance from liquid biopsies with Archer® Reveal ctDNA™. Learn more today.

Archer Reveal ctDNA 28

  • Published on Monday, February 13, 2017
The Archer® Reveal ctDNA™ 28 Kit for Illumina® is an advanced and user-friendly solution for targeted next generation sequencing (NGS) of circulating cell-free tumor DNA (ccfDNA/cfDNA/ctDNA) from 28 genes commonly found mutated in solid tumor type cancers.


Video: Detecting meaningful mutations from liquid biopsies by Anchored Multiplex PCR

  • Published on Monday, January 23, 2017
In this webinar, Josh Stahl and Jonathan Doose from ArcherDX will describe AMP-based ctDNA library preparation method


Clinical Tumor Sequencing: Applications and considerations for targeted sequencing using Anchored Multiplex PCR

  • Published on Friday, November 4, 2016
In this webinar, Dr. Patrick Hurban, Senior Director and Global Head of Genomic Development & Esoteric Assays at Q2 Solutions reviews multiple applications of AMP-based NGS performed in a global CRO, discussing assay suitability and performance for multiple disease and mutation types.


Clinical offerings at the Jackson Laboratory: Validation of the Archer® FusionPlex® Solid Tumor Panel

  • Published on Thursday, October 6, 2016
In this webinar Dr. Honey V Reddi explores the JAX® clinical genomics program with a look into the validation of the Archer FusionPlex solid tumor kit for Next Generation Sequencing (NGS)


Characterizing Hematologic Driver Mutations With Archer® Blood Cancer Assays

  • Published on Friday, August 19, 2016
Dr. Laura Griffin and Darius Fugere discuss the different hematological disease states, their biology, driver mutations and current detection methods. They also share data demonstrating how Archer Blood Cancer NGS Assays enable detection of all driver mutation types.


FLT3-ITD Detection With Archer® Blood Cancer Assays

  • Published on Friday, August 19, 2016
The molecular landscape of leukemia and lymphoma has expanded exponentially in the last two decades, and the complexity and scope of biomarkers makes molecular analysis difficult for any single approach. Archer FusionPlex and VariantPlex assays are powered by Anchored Multiplex PCR (AMP™) target enrichment chemistry to detect multiple mutation types and gene expression profiling in a single sample.


Next Generation Sequencing Applications and Sample Prep Workflow Improvements

  • Published on Wednesday, May 18, 2016
Josh Stahl, Chief Scientific Officer and General Manager at ArcherDX, discusses the challenges of detecting gene fusions from FFPE samples, the advantages of using Archer™ FusionPlex™ assays and how high-quality nucleic acid purification results in longer reads and higher-complexity libraries.


Archer Analysis Unlimited

  • Published on Tuesday, May 17, 2016
Analysis Unlimited is a private, cloud-based instance of the Archer Analysis bioinformatics suite efficiently configured to handle hundreds of samples simultaneously. Get the fastest analysis times without any expensive hardware or associated maintenance with Analysis Unlimited.


Archer™ Analysis - Processing Time

  • Published on Tuesday, April 5, 2016
Doug Wendel, Senior director of software at Archer, explains the differences between the four different installations of Archer Analysis. You can now get the most out of your bioinformatic software tools and only pay for as little or as much as you need. Take your fusion and mutation discovery to the next level with Archer Analysis.


Archer™ Analysis - View and filter variants

  • Published on Tuesday, April 5, 2016
In Analysis 4.0 it's now easier than ever to view and filter variants. In this video, Violet Roskens demonstrates how to create and save filter sets, organize bioinformatic data, and export and view your data in external applications.


Why RNA is better for fusion detection

  • Published on Friday, November 13, 2015
Why do Archer FusionPlex™ assays use RNA instead of DNA for input material? It all comes down to biological relevance, cost, and turn-around time. See why RNA is better for fusion detection than DNA-based hybrid capture techniques.


AMP is better: Strand Specificity

  • Published on Thursday, August 13, 2015
See how Anchored Multiplex PCR (AMP™) chemistry is better than traditional opposing primer-based enrichment, because strand-specific priming allows you to identify and correct for deamination events that would otherwise lease to false-positive results.


Comprehensive Tumor Profiling

  • Published on Wednesday, July 29, 2015
Learn how using Archer™ FusionPlex™ RNA assays and VariantPlex™ DNA assays in parallel makes it possible to generate comprehensive target-enriched libraries for next-generation sequencing to detect clinically relevant fusions, CNVs, SNVs and indels.


FusionPlex Anchored Multiplex PCR (AMP) Chemistry

  • Published on Wednesday, July 29, 2015
Learn how the FusionPlex system utilizes Anchored Multiplex PCR chemistry to create target enriched RNA libraries for next-generation sequencing.


VariantPlex Anchored Multiplex PCR (AMP) Chemistry

  • Published on Wednesday, July 29, 2015
Learn how the Archer VariantPlex system uses Anchored Multiplex PCR, which utilizes a combination of gene specific primers and half-functional universal adapters to create target enriched DNA libraries for next generation sequencing.


VariantPlex Workflow

  • Published on Monday, July 20, 2015
Learn the proper steps and processes for targeted DNA library preparation using the Archer VariantPlex system. By using Anchored Multiplex PCR and a modular design, you can rapidly create target enriched libraries from genomic DNA in just a few hours. After sequencing, analyze your data in Archer Analysis to identify CNVs, SNVs, and indels.


Learn more about Anchored Multiplex PCR (AMP™) chemistry to detect novel fusions, or go to Archer® FusionPlex® NGS assays to order fusion assays.

AMP is better for novel gene fusion detection

  • Published on Friday, July 17, 2015
Anchored Multiplex PCR enables the detection of targets of interest, including any known or novel fusion partners by using target-specific primers uni-directional primers, along with reverse primers, that hybridize to the sequencing adapter that is ligated to each fragment prior to amplification.


Archer Custom Panels used by Baby Genes™ CLIA-certified lab

  • Published on Tuesday, June 30, 2015
BabyGenes, Inc., is a Colorado-based company that provides quick supplemental next-generation sequencing (NGS)-based newborn screening. In this video, Rich Sjogren, CEO, and Angie Purvis, PhD, Associate Laboratory Director, discuss state-mandated newborn screening and the NGS-based service that Baby Genes provides, as well as why Archer Custom Panels were the right choice for their panel needs.


The Archer VariantPlex Solid Tumor NGS Panel

  • Published on Thursday, July 2, 2015
The VariantPlex Solid Tumor Panel is a targeted DNA sequencing assay that simultaneously detects and characterizes CNVs, SNPs and indels in 67 genes associated with solid tumors.


Archer Analysis - Starting a new job

  • Published on Monday, April 6, 2015
Want to see how to start a new Archer Analysis job? Field Application Specialist Ashleigh Teator, Ph.D., walks you through the process.


Archer Molecular Barcode Adapters

  • Published on Thursday, March 12, 2015
Archer Anchored Multiplex PCR (AMP) technology utilizes Molecular Barcode (MBC) Adapters for error correction, sample identification, de duplication, and advanced analysis in targeted sequencing NGS applications


Archer Analysis - JBrowse walkthrough

  • Published on
Archer Analysis provides the ability to visualize your NGS data directly in your browser window using the open-source tool JBrowse. With JBrowse you can access information to your targeted sequencing data right down to single-base levels, and give your fusion data greater clarity.


Find our fit.
Get true NGS assay customization with Archer® Assay Designer. Learn more today.

Archer FusionPlex Custom Panels Overview

  • Published on Tuesday, March 10, 2015
Use the Archer Assay Designer to create FusionPlex custom panels to detect and characterize specific gene fusions in your samples by next-generation sequencing


Agencourt FormaPure FFPE Sample Preparation Protocol

  • Published on Wednesday, February 11, 2015
Learn about how to use the FormaPure kit to purify nucleic acid from formalin-fixed paraffin-embedded tissues to prepare target-enriched libraries using Archer NGS assays.


Anchored Multiplex PCR chemistry

  • Published on Wednesday, January 21, 2015
Anchored Multiplex PCR (AMP) uses gene-specific primers and half-functional universal adapters to generate DNA libraries that are enriched for specific targets and any unknown fusion partners, which can then be detected by next-generation sequencing.


The value of richer NGS data sets using Anchored Multiplex PCR

  • Published on Wednesday, January 21, 2015
In this webinar, Dr. Kudlow discusses catalog and custom Archer™ products built upon the AMP™ technology and reviews the scope and power of the data generated with this technology. Anchored Multiplex PCR (AMP™) is a novel technology to prepare target-enriched libraries from both RNA and DNA inputs for gene rearrangement detection and characterization by next-generation sequencing (NGS). AMP™ enriches for target fragments by PCR using an adapter that is ligated at random locations and target-specific primers. This method of library preparation confers numerous advantages over amplicon-based library construction in both the downstream data analysis as well as the scalability of translocation detection assays.

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All content © 2018 ArcherDX, Inc.

For Research Use Only. Not for use in diagnostic procedures. For Research Use Only. Not for use in diagnostic procedures.