Anchored Multiplex PCR (AMP™)-based target enrichment preferentially enriches for highly fragmented ctDNA over high molecular weight genomic DNA to reduce background and increase detection sensitivity of low-allele fraction (AF) mutations.
NGS-ready libraries can be prepared in under 8 hours with less than 1 hour of hands-on time, providing sequencing results in as little as 3 days.
Molecular barcode sequences ligated prior to amplification enable duplicate read binning and advanced error correction for confident variant calls.
Reliably detect high AF (5%) variants using as little as 5ng total cfDNA input and low AF (1%) variants from as little as 10ng.
The Archer LiquidPlex Concordance panel combines Archer VariantPlex® with LiquidPlex for powerful copy number and variant detection from solid tumors and sensitive mutation detection from ctDNA, respectively. The panel also includes the Archer PreSeq® DNA QC Assay to prescreen DNA FFPE samples prior to library prep.
