Comprehensive Thyroid & Lung
The VariantPlex Comprehensive Thyroid and Lung (CTL) panel is a targeted next-generation sequencing (NGS) product to detect copy number variations (CNVs), single-nucleotide variants (SNVs) and indels in 31 thyroid and lung cancer-implicated genes. The panel covers entire targeted exons while maintaining high coverage uniformity (> 95%) and on-target reads (99.9%). When used alongside the ribonucleic acid (RNA)-based FusionPlex® CTL panel, fusions, SNVs, CNVs and expression profiles can be analyzed from a single low-input FFPE sample.
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- Key Features
- Specifications
- Gene Targets
- Additional Resources
Quantitative CNV Detection
Molecular barcoded fragment counting provides robust copy number analysis.
Expert Primer Design
Includes intronic buffers, complete target region coverage and high coverage uniformity.
Low Input
Anchored Multiplex PCR (AMP™)chemistry was purpose-built for wide sample type compatibility, including low-input and degraded samples such as FFPE tissue from fine needle aspirates (FNAs).
Orthogonal Validation
Confirm relevant CNV and SNV calls when using the companion FusionPlex CTL panel.
Properties
Specifications
Gene Targets
31
Input DNA Required
≤10ng
Total Target Size
~21.6kb
Coverage Uniformity >20% mean
>97%
Hands-On Time
2.5 Hour
Total Time
1 Day
Platform
Illumina
Sample Types
Fresh frozen and FFPE
*Input recommendations for FFPE samples vary depending on PreSeq® RNA QC score; 50ng input recommended in absence of PreSeq screening
AKT1
ALK
BRAF
CCND1
CTNNB1
DDR2
EGFR
EIF1AX
ERBB2
FGFR1
FGFR2
FGFR3
GNAS
HRAS
IDH1
IDH2
KIT
KRAS
MAP2K1
MDM2
MET
NRAS
PDGFRA
PIK3CA
PTEN
RET
ROS1
STK11
TERT
TP53
TSHR
LEGEND
SNV/Indel CNV
Product Information
Illumina
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