Comprehensive Thyroid & Lung
The VariantPlex Comprehensive Thyroid and Lung (CTL) panel is a targeted next-generation sequencing (NGS) product to detect copy number variations (CNVs), single-nucleotide variants (SNVs) and indels in 31 thyroid and lung cancer-implicated genes. The panel covers entire targeted exons while maintaining high coverage uniformity (> 95%) and on-target reads (99.9%). When used alongside the ribonucleic acid (RNA)-based FusionPlex® CTL panel, fusions, SNVs, CNVs and expression profiles can be analyzed from a single low-input FFPE sample.
Quantitative CNV Detection
Molecular barcoded fragment counting provides robust copy number analysis.
Expert Primer Design
Includes intronic buffers, complete target region coverage and high coverage uniformity.
Anchored Multiplex PCR (AMP™)chemistry was purpose-built for wide sample type compatibility, including low-input and degraded samples such as FFPE tissue from fine needle aspirates (FNAs).
Confirm relevant CNV and SNV calls when using the companion FusionPlex CTL panel.
Input cfDNA Required
Total Target Size
Coverage Uniformity >20% mean
Fresh frozen and FFPE
+Expected coverage uniformity at the recommended read depth
*Input recommendations for FFPE samples vary depending on PreSeq® RNA QC score; 50ng input recommended in absence of PreSeq screening