VariantPlex Thyroid & Lung

Comprehensive Thyroid & Lung

The Archer® VariantPlex Comprehensive Thyroid and Lung (CTL) panel is a targeted next-generation sequencing (NGS) product to detect copy number variations (CNVs), single-nucleotide variants (SNVs) and indels in 31 thyroid and lung cancer-implicated genes. The panel covers entire targeted exons while maintaining high coverage uniformity (> 95%) and on-target reads (99.9%). When used alongside the ribonucleic acid (RNA)-based FusionPlex® CTL panel, fusions, SNVs, CNVs and expression profiles can be analyzed from a single low-input FFPE sample. 

  • Key Features
  • Specifications
  • Gene Targets
  • Additional Resources
Quantitative CNV Detection

Molecular barcoded fragment counting provides robust copy number analysis.

Expert Primer Design

Includes intronic buffers, complete target region coverage and high coverage uniformity.

Low Input

Anchored Multiplex PCR (AMP™)chemistry was purpose-built for wide sample type compatibility, including low-input and degraded samples such as FFPE tissue from fine needle aspirates (FNAs).

Orthogonal Validation

Confirm relevant CNV and SNV calls when using the companion FusionPlex CTL panel.

Properties

Specifications

Gene Targets
31
Input cfDNA Required
≤10ng
Total Target Size
~21.6kb
Coverage Uniformity >20% mean
>97%
Hands-On Time
2.5 Hour
Total Time
1 Day
Platform
Illumina
Sample Types
Fresh frozen and FFPE

+Expected coverage uniformity at the recommended read depth
*Input recommendations for FFPE samples vary depending on Archer PreSeq® RNA QC score; 50ng input recommended in absence of PreSeq screening

AKT1

ALK

BRAF

CCND1

CTNNB1

DDR2

EGFR

EIF1AX

ERBB2

FGFR1

FGFR2

FGFR3

GNAS

HRAS

IDH1

IDH2

KIT

KRAS

MAP2K1

MDM2

MET

NRAS

PDGFRA

PIK3CA

PTEN

RET

ROS1

STK11

TERT

TP53

TSHR

LEGEND

   SNV/Indel
   CNV

Product Information
Illumina
  • AB0077 - 8-reactions
  • AB0081 - 48-reactions
  • AB0079 - 16-reactions – Ask about our starter panel​​​
Archer® Analysis

Need to modify your panel?

Add any of our wet lab-validated designs to this panel with Archer Assay Designer to build an assay that fits your exact requirements.

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For Research Use Only. Not for use in diagnostic procedures.

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For Research Use Only. Not for use in diagnostic procedures.